Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate P.W. Collins, C. Solomon, K.

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Theoretical modelling of fibrinogen supplementation with therapeutic plasma, cryoprecipitate, or fibrinogen concentrate P.W. Collins, C. Solomon, K. Sutor, D. Crispin, G. Hochleitner, S. Rizoli, H. Schöchl, M. Schreiber, M. Ranucci British Journal of Anaesthesia Volume 113, Issue 4, Pages 585-595 (October 2014) DOI: 10.1093/bja/aeu086 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Plot from unrefined version of the Excel-based fibrinogen concentration simulator. Values in cells highlighted grey are specified by the user; the graph is plotted based on these parameters. Cryo, cryoprecipitate; FFP, fresh-frozen plasma; Fib, fibrinogen; FibCon, fibrinogen concentrate. British Journal of Anaesthesia 2014 113, 585-595DOI: (10.1093/bja/aeu086) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Finalized Excel-based FCSamount and FCSlevel after implementation of refinements. (a) Fibrinogen concentration simulator (FCSamount): calculation of amount of haemostatic agent; (b) haematocrit graph from FCSamount; (c) FCSlevel: calculation of resultant plasma fibrinogen level. Values in cells highlighted light grey are specified by the user; the graphs are plotted based on these parameters. Cryo, cryoprecipitate; Fib, fibrinogen; FibCon, fibrinogen concentrate; RBC, red blood cell. British Journal of Anaesthesia 2014 113, 585-595DOI: (10.1093/bja/aeu086) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Finalized Excel-based FCSamount and FCSlevel after implementation of refinements. (a) Fibrinogen concentration simulator (FCSamount): calculation of amount of haemostatic agent; (b) haematocrit graph from FCSamount; (c) FCSlevel: calculation of resultant plasma fibrinogen level. Values in cells highlighted light grey are specified by the user; the graphs are plotted based on these parameters. Cryo, cryoprecipitate; Fib, fibrinogen; FibCon, fibrinogen concentrate; RBC, red blood cell. British Journal of Anaesthesia 2014 113, 585-595DOI: (10.1093/bja/aeu086) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Finalized Excel-based FCSamount and FCSlevel after implementation of refinements. (a) Fibrinogen concentration simulator (FCSamount): calculation of amount of haemostatic agent; (b) haematocrit graph from FCSamount; (c) FCSlevel: calculation of resultant plasma fibrinogen level. Values in cells highlighted light grey are specified by the user; the graphs are plotted based on these parameters. Cryo, cryoprecipitate; Fib, fibrinogen; FibCon, fibrinogen concentrate; RBC, red blood cell. British Journal of Anaesthesia 2014 113, 585-595DOI: (10.1093/bja/aeu086) Copyright © 2014 The Author(s) Terms and Conditions