Modeling the cancer patient with genetically engineered mice Reade B Roberts, Carlos L Arteaga, David W Threadgill  Cancer Cell  Volume 5, Issue 2, Pages 115-120 (February 2004) DOI: 10.1016/S1535-6108(04)00032-7

Figure 1 Developmental skin defects in Egfr-deficient mice (A and C) and skin toxicity in patients treated with EGFR inhibitors (B and D) Gross images of severe skin and hair pathology in a Egfr mutant mouse (A) and folliculitis in a patient susceptible to EGFR inhibition therapy induced skin toxicity (B). Comparative histology of hair follicle in Egfr nullizygous skin (C) and follicle from patient with EGFR therapy-induced folliculitis (D). Rupture of follicular epithelium and strong mixed inflammatory response are evident in both C and D. (B) reprinted with permission from the American Society of Clinical Oncology (Baselga et al., 2002); (C) provided by Laura Hansen (Creighton University); and (D) reprinted with permission from Blackwell Publishing (Busam et al., 2001). Cancer Cell 2004 5, 115-120DOI: (10.1016/S1535-6108(04)00032-7)