Skeletal muscle contractility and fatigability in adults with cystic fibrosis Mathieu Gruet, Nicolas Decorte, Laurent Mely, Jean-Marc Vallier, Boubou.

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Skeletal muscle contractility and fatigability in adults with cystic fibrosis Mathieu Gruet, Nicolas Decorte, Laurent Mely, Jean-Marc Vallier, Boubou Camara, Sébastien Quetant, Bernard Wuyam, Samuel Verges Journal of Cystic Fibrosis Volume 15, Issue 1, Pages e1-e8 (January 2016) DOI: 10.1016/j.jcf.2015.05.004 Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Schematic illustration of the neuromuscular protocol. Pre exercise neuromuscular evaluation consisted of two maximal voluntary contractions (MVC) with femoral nerve magnetic stimulations delivered at different frequencies in both contracted and relaxed muscle. See the text for the exact timing. This neuromuscular evaluation was repeated after each fatiguing set, at exhaustion (Exh) and after 10min of recovery (Post 10). The fatiguing task consisted of sets of 10 intermittent (5-s on/5-s off) isometric contractions at submaximal target force levels, starting at 10% MVC with increment of 10% MVC each set until exhaustion. Journal of Cystic Fibrosis 2016 15, e1-e8DOI: (10.1016/j.jcf.2015.05.004) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Changes in maximum voluntary contraction (MVC, panel A) and potentiated twitch amplitude (Twp, panel B) evoked by femoral nerve magnetic stimulation in the relaxed muscle at baseline (Pre), during the fatiguing task after each set, immediately after exhaustion (Exh) and after 10min of recovery (P10), in cystic fibrosis (CF) patients (MVC, n=15; Twp, n=13) and controls (MVC, n=15; Twp, n=13). * Time effect, significantly different from Pre (P<0.05); # Time effect, significant difference between Exh and P10 (P<0.05). Journal of Cystic Fibrosis 2016 15, e1-e8DOI: (10.1016/j.jcf.2015.05.004) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Changes in doublets at 100Hz (DB100, panel A), 10Hz (Db10, panel B), ratio between doublets at 10Hz and 100Hz (Db10:100, panel C) and maximal M-wave amplitude (Mmax, panel D) evoked by femoral nerve magnetic stimulation at baseline (Pre), during the fatiguing task after each set, immediately after exhaustion (Exh) and after 10min of recovery (P10), in cystic fibrosis (CF) patients (all n=12, except Mmax, n=13) and controls (all n=12, except Mmax, n=13). * Time effect, significantly different from Pre (P<0.05); # time effect, significant difference between Exh and P10 (P<0.05). Journal of Cystic Fibrosis 2016 15, e1-e8DOI: (10.1016/j.jcf.2015.05.004) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions