R.J.Ni Mhuircheartaigh, R.A. Moore, H.J. McQuay

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Presentation transcript:

Analysis of individual patient data from clinical trials: epidural morphine for postoperative pain R.J.Ni Mhuircheartaigh, R.A. Moore, H.J. McQuay British Journal of Anaesthesia Volume 103, Issue 6, Pages 874-881 (December 2009) DOI: 10.1093/bja/aep300 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 (a and b) Each individual’s mean pain score over the 10 time points analysed by treatment group. (c and d) Each individual’s mean pain score displayed for the three ‘clinically relevant’ treatment groups by postoperative day and overall. Pain scores were recorded at rest (a and c) and with activity (b and d). Boxplots represent the interquartile range (IQR) with whiskers extending 1.5 IQR. Medians are shown as a horizontal line and means as ♦. *P<0.05; P, placebo; MS, 5 mg epidural morphine sulphate; 5, 10, 15 etc., mg dose of EREM. British Journal of Anaesthesia 2009 103, 874-881DOI: (10.1093/bja/aep300) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 (a) Each individual’s rescue analgesia use over 48 h analysed by the treatment group. (b) Comparison for clinically relevant groups on first and second postoperative days. Boxplots represent the IQR with whiskers extending 1.5 IQR from the box. Medians are shown as a horizontal line and means as a diamond. *P<0.05. British Journal of Anaesthesia 2009 103, 874-881DOI: (10.1093/bja/aep300) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 Incidence of pruritus, nausea, vomiting, urinary retention, and respiratory depression in each treatment group (P, placebo; MS, 5 mg epidural morphine sulphate; 5, 10, 15 etc., mg dose of EREM) and severity (white, mild, moderate, and severe; black, moderate and severe only). British Journal of Anaesthesia 2009 103, 874-881DOI: (10.1093/bja/aep300) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 4 (a) Median and IQR of patient mean VAS scores over 48 h at rest (white) and on movement (black), grouped by subjective rating of pain medication. (b) Median and IQR of IVPCA fentanyl use over 48 h grouped by subjective rating of pain medication. British Journal of Anaesthesia 2009 103, 874-881DOI: (10.1093/bja/aep300) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions