The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: The role of the endothelium and reactive oxygen.

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Presentation transcript:

The effect of elevated homocysteine levels on adrenergic vasoconstriction of human resistance arteries: The role of the endothelium and reactive oxygen species Marilyn J. Cipolla, PhD, W.Kent Williamson, MD, Mark L. Nehler, MD, Lloyd M. Taylor, MD, John M. Porter, MD Journal of Vascular Surgery Volume 31, Issue 4, Pages 751-759 (April 2000) DOI: 10.1067/mva.2000.103797 Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Graph showing the concentration-response to norepinephrine (NE ) of arteries in PSS (control ; ●) and exposed to 200 μmol/L homocysteine (HC ; ○). *P <.05; **P <.01. Journal of Vascular Surgery 2000 31, 751-759DOI: (10.1067/mva.2000.103797) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Graph showing the concentration-response to norepinephrine (NE ) of arteries exposed to 200 μmol/L homocysteine (HC ) in the absence (○) and presence (▵) of 1200 U/mL catalase and 120 U/mL SOD. Journal of Vascular Surgery 2000 31, 751-759DOI: (10.1067/mva.2000.103797) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Graph showing the concentration-response to acetylcholine (ACh ) of arteries in PSS (control ; ●) and in 200 μmol/L homocysteine (HC ), (○). Journal of Vascular Surgery 2000 31, 751-759DOI: (10.1067/mva.2000.103797) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Graph showing the concentration-response to SNP of arteries in PSS (control ; ●) and exposed to 200 μmol/L homocysteine (HC ; ○). Journal of Vascular Surgery 2000 31, 751-759DOI: (10.1067/mva.2000.103797) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 Diameter tracing of a denuded artery contracted with norepinephrine (NE ) and given a single concentration (150 μmol/L) of homocysteine (HC ), demonstrating the vasodilating effect of homocysteine. Journal of Vascular Surgery 2000 31, 751-759DOI: (10.1067/mva.2000.103797) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 6 Graph showing the concentration-response characteristics to homocysteine (HC ) of both intact (●) and denuded (○) arteries. Arteries were contracted with an intermediate concentration of norepinephrine (NE ), and homocysteine was added cumulatively to the arteriograph bath. *P <.05; **P <.01. Journal of Vascular Surgery 2000 31, 751-759DOI: (10.1067/mva.2000.103797) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions