Mechanism of Triton binding to ShHTL7

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Presentation transcript:

Mechanism of Triton binding to ShHTL7 Mechanism of Triton binding to ShHTL7 Crystal structure of ShHTL7 (gray) bound to Triton (stick model; green: carbons; red: oxygens).Surface (protein) and sphere (Triton) representation of (A) tilted by ˜10° toward the viewer.Zoom into the ShHTL7 binding pocket. Key side chains and Triton are shown as stick models. Red spheres depict ordered water molecules.LigPlot of the ShHTL7‐Triton interactions. Hydrophobic interactions: red arc with spokes radiating toward the ligand atoms involved; hydrogen bonds: dashed lines.Multiple sequence alignment of the ShHTL7 SL binding site against homologs from various species. Red residues: similar stereochemical character. Boxed: highly conserved positions. Residues marked with a star contribute to Triton interactions. For a full alignment, see Fig EV2. Umar Shahul Hameed et al. EMBO Rep. 2018;embr.201745619 © as stated in the article, figure or figure legend