Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection J.T.A. Mäkelä, Z.S.

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Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection J.T.A. Mäkelä, Z.S. Rezaeian, S. Mikkonen, R. Madden, S.-K. Han, J.S. Jurvelin, W. Herzog, R.K. Korhonen Osteoarthritis and Cartilage Volume 22, Issue 6, Pages 869-878 (June 2014) DOI: 10.1016/j.joca.2014.04.010 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Analyzed locations in the lapine knee joints. Articular cartilage samples in the lateral and medial femoral condyles (A), tibial plateaus (B) and femoral groove (C) were biomechanically tested and used for determinations of tissue structure and composition. Indentation locations are marked with black dots, while the directions of slices prepared for microscopy and spectroscopy are marked with solid lines. Spaces between lines are not to scale. Osteoarthritis and Cartilage 2014 22, 869-878DOI: (10.1016/j.joca.2014.04.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Microscopic images of safranin O stained sections (left), collagen orientation maps (center) and amide I absorption maps (right) used to analyze PG content, collagen orientation angle and collagen content, respectively, using digital densitometry (DD), polarized light microscopy (PLM) and Fourier Transform Infrared (FTIR) spectroscopy. Representative examples from ACLT, C-L and CNTRL groups have been presented. Osteoarthritis and Cartilage 2014 22, 869-878DOI: (10.1016/j.joca.2014.04.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Mean values (and 95% CI) of PG content profiles in different groups and sites measured with digital densitometry. Dashed line in the top shows spatially significant differences between two groups of those colors (P < 0.05). Osteoarthritis and Cartilage 2014 22, 869-878DOI: (10.1016/j.joca.2014.04.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Mean values (and 95% CI) of collagen orientation profiles in different groups and sites measured with polarized microscopy. Dashed line in the top shows spatially significant differences between two groups of those colors (P < 0.05). Osteoarthritis and Cartilage 2014 22, 869-878DOI: (10.1016/j.joca.2014.04.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Mean values (and 95% CI) of collagen content profiles in different groups and sites measured with FTIR. Dashed line in the top shows spatially significant difference between two groups of those colors (P < 0.05). Osteoarthritis and Cartilage 2014 22, 869-878DOI: (10.1016/j.joca.2014.04.010) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions