A Developmental Switch in Microglial HDAC Function

Slides:

Advertisements

Similar presentations

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer Shaun K. Olsen, Christopher D. Lima Molecular Cell Volume 49, Issue 5, Pages.

Advertisements

How T Cells Earn the Follicular Rite of Passage Carola G. Vinuesa, Jason G. Cyster Immunity Volume 35, Issue 5, Pages (November 2011) DOI: /j.immuni

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2 Meghan A. Koch, Kerri R. Thomas, Nikole R.

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz,

Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development Xavier Morin, Yohanns Bellaïche Developmental Cell Volume.

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis Wing-Hang Tong, Tracey A. Rouault Cell.

The Transcription Factor Foxo1 Controls Central-Memory CD8+ T Cell Responses to Infection Myoungjoo V. Kim, Weiming Ouyang, Will Liao, Michael Q. Zhang,

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation Timotheus Y.F. Halim, Ramona.

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology Andrew G. Manford, Christopher J. Stefan, Helen L. Yuan, Jason A. MacGurn,

Human Epidermal Langerhans Cells Maintain Immune Homeostasis in Skin by Activating Skin Resident Regulatory T Cells Julien Seneschal, Rachael A. Clark,

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

Nuclear Receptors, RXR, and the Big Bang Ronald M. Evans, David J. Mangelsdorf Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial- Mesenchymal Transition Min-Zu Wu, Ya-Ping Tsai, Muh-Hwa Yang, Chi-Hung Huang,

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer’s disease mouse model by Gerhard Leinenga, and Jürgen Götz Sci Transl Med Volume.

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Is Early Placement Better in Alzheimer's Disease?

Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges

Human Induced Pluripotent Stem Cells: Now Open to Discovery

PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria

Testing the Amyloid Hypothesis with a Humanized AD Mouse Model

The Architects of B and T Cell Immune Responses

A Death Trap for Microglia

Upgrading from iMac to iMicro

Stop Press: Eosinophils Drafted to Join the Th17 Team

One Niche to Rule Both Maintenance and Loss of Stemness in HSCs

Microglia Current Biology

Chronic Infections Capture Little Attention of the Masses

A Flt3L Encounter: mTOR Signaling in Dendritic Cells

Juan Rivera, Lino Tessarollo Immunity

Human Induced Pluripotent Stem Cells: Now Open to Discovery

CD4 Helpers Put Tissue-Resident Memory Cells in Their Place

Cécile L. Maire, Keith L. Ligon Cancer Cell

Thymic Selection: To Thine Own Self Be True

A CRISPR Connection between Chromatin Topology and Genetic Disorders

A Rogue Foxp3 Mutant Undermines Treg Cell Function

Commanding CNS Invasion: GM-CSF

Amyloid Cascade into Clarity

Chronic Infections Capture Little Attention of the Masses

Making Mouse Models That Reflect Human Immune Responses

ILC1 Populations Join the Border Patrol

Myeloid Cells in the Central Nervous System

PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria

ILC Lineage Specification: To Be or Not 11b, That Is the Question

A Prescription for Human Immunology

Brandon J. Thomas, Stephen T. Smale Immunity

Driving Rel-iant Tregs toward an Identity Crisis

One Bug or Another: Promiscuous T Cells Form Lifelong Memory

Keeping Off the Weight with DCs

Learning from the Uncontrollable

MicroRNA-155 Function in B Cells

Life-Saving Degeneracy in the Human Immune System

Chapter 29 - Stem Cells and Generation of New Cells in the

Regulatory T Cells GATA Have It

t Testing the Immune System

Chapter 77 Cervical Cancer: Burden of Disease

David Hubel and Torsten Wiesel

PTENtiating CFTR for Antimicrobial Immunity

Notch 1 Keeps Pro-T cells on Track

IL-9 by INFERence Immunity

Of Human DC Migrants and Residents

Presentation transcript:

A Developmental Switch in Microglial HDAC Function Hansruedi Mathys, Jay Penney, Li-Huei Tsai Immunity Volume 48, Issue 3, Pages 476-478 (March 2018) DOI: 10.1016/j.immuni.2018.03.010 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 HDACs 1 and 2 Are Essential for Microglia Development, but Their Loss in Adult Microglia Reduces Pathology in a Mouse Model of Alzheimer’s Disease Genetic deletion of Hdac1 and Hdac2 in microglia prior to birth strongly impairs microglial development, resulting in reduced cell numbers and altered morphology (left). In contrast, deletion of Hdac1 and Hdac2 in adult microglia has no effect on cell number or morphology during homeostasis (middle). Hdac1-2 deletion from adult microglia in Alzheimer’s disease model mice reduces amyloid plaque burden, increases amyloid co-localization with microglia, and rescues cognitive deficits (right). Immunity 2018 48, 476-478DOI: (10.1016/j.immuni.2018.03.010) Copyright © 2018 Elsevier Inc. Terms and Conditions