Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Yan Yan, Ziyad Al-Aly

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Presentation transcript:

Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus Yan Xie, Benjamin Bowe, Tingting Li, Hong Xian, Yan Yan, Ziyad Al-Aly Kidney International Volume 93, Issue 3, Pages 741-752 (March 2018) DOI: 10.1016/j.kint.2017.08.033 Copyright © 2017 Terms and Conditions

Figure 1 Diabetes-free survival curves by time-updated estimated glomerular filtration rate (eGFR) categories (eGFR in ml/min per 1.73 m2). Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions

Figure 2 Diabetes-free survival curves by time-updated blood urea nitrogen (BUN) categories; BUN in mg/dl. Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions

Figure 3 Spline analysis of the relationship between time-updated estimated glomerular filtration rate (eGFR) and risk of incident diabetes mellitus. The red line represents the hazard ratio, and dashed blue lines represent 95% confidence intervals. eGFR = 120 ml/min per 1.73 m2 was the reference. Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions

Figure 4 Spline analysis of the relationship between time-updated blood urea nitrogen (BUN) and risk of incident diabetes mellitus. The red line represents the hazard ratio, and dashed blue lines represent 95% confidence intervals. BUN = 5 mg/dl was the reference. Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions

Figure 5 Spline analysis of risk of incident diabetes mellitus including both time-updated estimated glomerular filtration rate (eGFR) and blood urea nitrogen (BUN). eGFR = 120 ml/min per 1.73 m2 and BUN = 5 mg/dl were the reference points. Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions

Figure 6 Diabetes-free survival curves by baseline blood urea nitrogen (BUN) categories; BUN in mg/dl. Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions

Figure 7 Spline analysis of the relationship between baseline blood urea nitrogen (BUN) and risk of incident diabetes mellitus. The red line represents the hazard ratio, and dashed blue lines represent 95% confidence intervals. BUN = 5 mg/dl was the reference. Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions

Figure 8 Flowchart of cohort assembly. VA, Veterans Affairs. Kidney International 2018 93, 741-752DOI: (10.1016/j.kint.2017.08.033) Copyright © 2017 Terms and Conditions