A new era in the treatment of calcium oxalate stones?

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Presentation transcript:

A new era in the treatment of calcium oxalate stones? Ognen Ivanovski, Tilman B. Drüeke Kidney International Volume 83, Issue 6, Pages 998-1000 (June 2013) DOI: 10.1038/ki.2013.41 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Proposed mechanism of oxalate handling across the liver, stomach, intestinal tract, and kidney. Dietary oxalate is absorbed from the gut via members of the solute-linked carrier 26 (SLC26) anion-exchanging family. The serum oxalate delivered from both exogenous and endogenous sources (gut and liver, respectively) is rapidly excreted by the kidney, via both glomerular filtration and tubular secretion. Excessive urinary concentrations of oxalate and calcium lead to development of calcium oxalate kidney stones. Oxalobacter formigenes is destroying oxalic acid and is able to induce oxalate secretion/excretion in the colon. Note that different members of the SLC26 anion-exchanging family are involved in oxalate handling, depending on each intestinal segment and renal tubular segment. AGT, alanine:glyoxylate transferase; GRHPR, glyoxylate reductase/hydroxypyruvate reductase. Kidney International 2013 83, 998-1000DOI: (10.1038/ki.2013.41) Copyright © 2013 International Society of Nephrology Terms and Conditions