Daniel J. Jackson, MD, James E. Gern, MD, Robert F. Lemanske, MD

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Presentation transcript:

The contributions of allergic sensitization and respiratory pathogens to asthma inception Daniel J. Jackson, MD, James E. Gern, MD, Robert F. Lemanske, MD Journal of Allergy and Clinical Immunology Volume 137, Issue 3, Pages 659-665 (March 2016) DOI: 10.1016/j.jaci.2016.01.002 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Interplay between FcεRI and antiviral responses. In normal airways plasmacytoid dendritic cells (pDCs) are major sources of type I and type III interferons in response to viral infections. These cells also have low-level expression of FcεRI. In the context of allergy, pDCs express greater FcεRI, which is inversely related to interferon responses. In addition, cross-linking of FcεRI further reduces interferon responses. Consequences of suppressed interferon responses to viral infection could include increased viral replication, more severe illnesses with wheezing, and exacerbation of pre-existing asthma. Journal of Allergy and Clinical Immunology 2016 137, 659-665DOI: (10.1016/j.jaci.2016.01.002) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions