Michael I. Ebright, MD, Jonathan S

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Replication-competent herpes virus NV1020 as direct treatment of pleural cancer in a rat model Michael I. Ebright, MD, Jonathan S. Zager, MD, Sandeep Malhotra, MD, Keith A. Delman, MD, Tracey L. Weigel, MD, Valerie W. Rusch, MD, Yuman Fong, MD The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 1, Pages 123-129 (July 2002) DOI: 10.1067/mtc.2002.122297 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 In vitro cytotoxicity of NV1020 against A549 cells expressed as a fraction of control. Cell counts were measured daily for 7 days. Assays were performed in triplicate, and error bars indicate SEM. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 123-129DOI: (10.1067/mtc.2002.122297) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 NV1020 replication in A549 cells after in vitro infection with an MOI of 1.0 (5 × 104 PFU). Viral titers were evaluated by means of standard plaque assay. Assays were performed in triplicate, and error bars indicate SEM. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 123-129DOI: (10.1067/mtc.2002.122297) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Mean intrapleural tumor weight in rats treated 3 hours after tumor inoculation. Rats were treated with intrapleural PBS, intravenous NV1020 (1 × 107 PFU), or intrapleural NV1020 (1 × 107 PFU). Error bars indicate SEM. The P value for the intravenous treated group is.29, and that for the intrapleural group is.001. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 123-129DOI: (10.1067/mtc.2002.122297) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Representative sections of tumor implants evident 3 days after intrapleural tumor inoculation. Shown are samples from mediastinal fat (A), chest wall (B), and diaphragm (C). (Original magnification 20×.) D is a representative section of pleural tumor from rats treated with intrapleural virus 72 hours earlier. Sections were analyzed by means of immunohistochemistry with a polyclonal anti-HSV primary antibody. Brown cells are positive for viral antigen. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 123-129DOI: (10.1067/mtc.2002.122297) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Mean intrapleural tumor weight in rats treated 3 days after tumor inoculation. Rats were treated with intrapleural PBS or intrapleural NV1020 (1 × 107 PFU). Error bars indicate SEM. P value with a nonparametric Wilcoxon test is.046. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 123-129DOI: (10.1067/mtc.2002.122297) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions