Heat-denatured albumin-coated Dacron vascular grafts: Physical characteristics and in vivo performance MAJ, MC, USA John D. Rumisek, M.D., Charles E.

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Presentation transcript:

Heat-denatured albumin-coated Dacron vascular grafts: Physical characteristics and in vivo performance MAJ, MC, USA John D. Rumisek, M.D., Charles E. Wade, Ph.D., Daniel E. Brooks, B.S., CPT, VC, USA Carlin V. Okerberg, D.V.M., Ph.D., COL, MC, USA Michael J. Barry, M.D., COL, MC, USA John S. Clarke, M.D. Journal of Vascular Surgery Volume 4, Issue 2, Pages 136-143 (August 1986) DOI: 10.1016/0741-5214(86)90413-1 Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Scanning electron micrographs show filamentous Dacron fabric before (A) and after (B) it was soaked in albumin and autoclaved. A thick, adherent protein coating, consisting of a continuous coagulum of heat-denatured albumin, penetrates interstices of the fabric and has uniform surface pitting. (Original magnifications, ×15.) Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Interstitial leak rates of various graft fabrics soaked in 25% albumin and then autoclaved. (Marlex and gauze required more than two layers.) Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Porosities of knitted (striped bar) vs. woven (solid bar) Dacron graft fabrics with autoclaving after immersion in 5% albumin, 25% albumin, or human plasma. Leak rate of knitted Dacron sealed with heat-denatured 5% albumin was too great to measure (more than 200 ml/min/cm2). Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Effect of increased transmural pressure on porosities of knitted (solid line) and woven (broken line) Dacron graft fabrics coated with heat-denatured 25% albumin and measured immediately after coating. Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Porosity of woven Dacron graft fabric measured immediately (solid line) and 2 hours after (broken line) coating with heat-denatured 5% albumin. Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 6 Scanning electron micrographs show surface of protein-coated fabric (A) that, despite diffuse 7 to 10 μm surface pits, presents more uniform and smoother flow surface than that of blood-preclotted fabric (B). (Original magnifications, ×600.) Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 7 Compound graft with little surrounding tissue reaction rests nearly totally free in retroperitoneum of one dog that died suddenly at 7 days. Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 8 Comparison of prostheses after harvest at 6 months shows no differences between blood-preclotted grafts (A) and albumin-sealed grafts (B). Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 9 This graft has subendothelial deposits of eosinophilic material. Single layer of endothelial cells lines graft lumen. (Original magnification, ×40.) Journal of Vascular Surgery 1986 4, 136-143DOI: (10.1016/0741-5214(86)90413-1) Copyright © 1986 Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions