The predictive value of nadir neutrophil count during treatment of cervical cancer: Interactions with tumor hypoxia and interstitial fluid pressure (IFP)

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The predictive value of nadir neutrophil count during treatment of cervical cancer: Interactions with tumor hypoxia and interstitial fluid pressure (IFP) Rachel Glicksman, Naz Chaudary, Melania Pintilie, Eric Leung, Blaise Clarke, Kieyan Sy, Richard P. Hill, Kathy Han, Anthony Fyles, Michael Milosevic Clinical and Translational Radiation Oncology Volume 6, Pages 15-20 (October 2017) DOI: 10.1016/j.ctro.2017.08.002 Copyright © 2017 Terms and Conditions

Fig. 1 Box plots for absolute neutrophil count (ANC) at baseline and weekly during external beam RT. The nadir ANC during external beam RT is also shown. The plots show the median value, first and third quartile values, 1.5times the interquartile range and outlying data points. Clinical and Translational Radiation Oncology 2017 6, 15-20DOI: (10.1016/j.ctro.2017.08.002) Copyright © 2017 Terms and Conditions

Fig. 2 Kaplan–Meier disease free survival (DFS) curves for baseline (left) and nadir (right) ANCs in all patients, divided into three equally sized groups. The hazard ratios (HRs) and p-values were obtained using the Cox proportional hazard model with baseline and nadir ANC as continuous variables. Clinical and Translational Radiation Oncology 2017 6, 15-20DOI: (10.1016/j.ctro.2017.08.002) Copyright © 2017 Terms and Conditions

Fig. 3 Kaplan–Meier disease free survival (DFS) curves for oxic (left), high IFP (middle) and oxic+high IFP tumors (right) stratified by nadir ANC. Oxic tumors had HP5 ≤55%. High IFP was defined as >18mmHg. Nadir ANC was analyzed as a continuous variable using the Cox proportional hazard model but, for illustrative purposes, displayed as three equally sized groups. The hazard ratios (HRs) and p-values were obtained from the Cox model after adjusting for important clinical covariates and treatment type. Clinical and Translational Radiation Oncology 2017 6, 15-20DOI: (10.1016/j.ctro.2017.08.002) Copyright © 2017 Terms and Conditions