Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer Steen Riisgaard.

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Presentation transcript:

Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer Steen Riisgaard de Blanck, Jonas Scherman Rydhög, Klaus Richter Larsen, Paul Frost Clementsen, Mirjana Josipovic, Marianne Camille Aznar, Per Munck af Rosenschöld, Rasmus Irming Jølck, Lena Specht, Thomas Lars Andresen, Gitte Fredberg Persson Clinical and Translational Radiation Oncology Volume 13, Pages 24-28 (November 2018) DOI: 10.1016/j.ctro.2018.07.004 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Example of ultrasound guided injection (EBUS probe) of liquid marker in a pig (A). Arrow 1 marks the needle tip and arrow 2 the liquid marker (A). B–D) Images of a patient with liquid markers injected into lymph node stations 4 L and 10 L: Anterior-posterior fluoroscopy projection with the markers encircled (B), axial plane from a computed tomography (C) and a cone beam computed tomography (D). Clinical and Translational Radiation Oncology 2018 13, 24-28DOI: (10.1016/j.ctro.2018.07.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Example of liquid fiducial marker (300 µL) implanted in a primary tumour. Axial images of the planning CT (left), the CBCT at fraction 32 (middle) and follow-up CT 21 months after treatment (right). Clinical and Translational Radiation Oncology 2018 13, 24-28DOI: (10.1016/j.ctro.2018.07.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Normalized values of marker volume (left) and –contrast (right) during follow up, showing a steady state in marker volume after 9 months and stable marker contrast values throughout the period. Clinical and Translational Radiation Oncology 2018 13, 24-28DOI: (10.1016/j.ctro.2018.07.004) Copyright © 2018 The Authors Terms and Conditions