CD8-Predominant T Cell Meningitis Accompanies Gvhd in Primates and Is Prevented with Immunoprophylaxis Saravanan Kaliyaperumal, Prachi Sharma, Benjamin.

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CD8-Predominant T Cell Meningitis Accompanies Gvhd in Primates and Is Prevented with Immunoprophylaxis Saravanan Kaliyaperumal, Prachi Sharma, Benjamin K. Watkins, MD, Scott N. Furlan, MD, Swetha Ramakrishnan, Cynthia Giver, Anapatricia Garcia, Cynthia Courtney, Kelly Hamby, Aneesah Garrett, Taylor Deane, Elizabeth Strobert, Joe Jenkins, Eric Elder, Natia Eishiavielli, Timothy Crenshaw, Bruce R. Blazar, MD, Edmund K. Waller, MD, PhD, Susan Westmoreland, VMD, Leslie S. Kean, MD, PhD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S270-S272 (February 2014) DOI: 10.1016/j.bbmt.2013.12.455 Copyright © 2014 Terms and Conditions

Figure 1 Meningeal inflammation of rhesus monkeys during acute GvHD is characterized by an infiltration of activated CD8+ lymphocytes that does not occur during GvHD prophylactic therapy. (A) Immunohistochemical stains for specific antibodies within the CNS meninges of animals undergoing various HSCT regimens and GvHD prophylactic regimens are shown. (B) Number of cells per 10X field were quantified and scored from 0 to 11 based on the number of positive cells (0= no cells; 1 = 1-5 cells; 2 = 6-10 cells; 3 = 11 - 15 cells; 4 = 16-20 cells; 5 = 21-25 cells; 6 = 26-30 cells; 7 = 31-35 cells; 8 = 36-40 cells; 9 = 41-45 cells; 10 = 46-50 cells, 11 = > 51 cells.). The p-values as calculated by Mann-Whitney test are represented above the respective bars;* indicates statistical significance (P <0.05). Biology of Blood and Marrow Transplantation 2014 20, S270-S272DOI: (10.1016/j.bbmt.2013.12.455) Copyright © 2014 Terms and Conditions

Figure 2 LFA-1 is highly expressed on activated CD8+ lymphocytes infiltrating CNS during acute GvHD in a non-human primate model. (A) Immunohistochemical stains for LFA-1 within the CNS menings of normal control and allogenic-HCT-no treatment animals B) Number of cells per 10X field were quantified and scored form 0 to 11 based on the number of positive cells (0= no cells; 1 = 1-5 cells; 2 = 6-10 cells; 3 = 11-15 cells; 4 = 16-20 cells; 5 = 21-25 cells; 6 = 26-30 cells; 7 = 31-35 cells; 8 = 36-40 cells; 9 = 41-45 cells; 10 = 46-50 cells; 11= > 51 cells.). The p-value as calculated by Mann-Whitney test is represented above the bar;* indicated statistical significance (P < 0.05). Biology of Blood and Marrow Transplantation 2014 20, S270-S272DOI: (10.1016/j.bbmt.2013.12.455) Copyright © 2014 Terms and Conditions