Uncalibrated pulse contour-derived stroke volume variation predicts fluid responsiveness in mechanically ventilated patients undergoing liver transplantation

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Presentation transcript:

Uncalibrated pulse contour-derived stroke volume variation predicts fluid responsiveness in mechanically ventilated patients undergoing liver transplantation M. Biais, K. Nouette-Gaulain, V. Cottenceau, P. Revel, F. Sztark British Journal of Anaesthesia Volume 101, Issue 6, Pages 761-768 (December 2008) DOI: 10.1093/bja/aen277 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Median values, interquartile range and individual values of baseline values of stroke volume variation (SVV) in responders (R) and non-responders (NR). * P<0.001 vs NR. British Journal of Anaesthesia 2008 101, 761-768DOI: (10.1093/bja/aen277) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Relationship between baseline values of stroke volume variation (SVV) and volume expansion (VE)-induced changes in cardiac output measured by TTE (CO-TTE), and between pulse pressure variation (PPV) and VE-induced changes in CO-TTE. British Journal of Anaesthesia 2008 101, 761-768DOI: (10.1093/bja/aen277) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Receiver operating characteristic curves comparing the ability of stroke volume variations (SVVs), pulse pressure variations (PPVs), central venous pressure (CVP) and pulmonary artery occlusion pressure (PAOP) before volume expansion to discriminate Rs and NRs (cardiac output measured with TTE). The best threshold values showing the ability of various haemodynamic parameters to predict fluid responsiveness were >10% for SVV, >12% for PPV, ≤10 mm Hg for PAOP, and ≤3 mm Hg for CVP. Areas under the ROC curve (95% CI) were 0.95 (0.81–0.99) for SVV, 0.98 (0.87–0.99) for PPV, 0.60 (0.42–0.76) for PAOP, and 0.64 (0.44–0.78) for CVP. British Journal of Anaesthesia 2008 101, 761-768DOI: (10.1093/bja/aen277) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Bland–Altman plots between (upper panels) cardiac output measured by transthoracic echocardiography (CO-TTE) and by Vigileo™ device (CO-Vigileo) and between (lower panels) cardiac output measured by pulmonary artery catheter (CO-PAC) and by Vigileo™ device (CO-Vigileo), before and after fluid challenge. The continuous lines show the mean difference (bias) and the dotted lines show the 95% limits of agreement (2×sd). British Journal of Anaesthesia 2008 101, 761-768DOI: (10.1093/bja/aen277) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions