Lipoxin A4 (LXA4) up-regulates aquaporin 5 (AQP5) and downregulates surfactant protein C but has no effect on receptor for advanced glycation end products.

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Lipoxin A4 (LXA4) up-regulates aquaporin 5 (AQP5) and downregulates surfactant protein C but has no effect on receptor for advanced glycation end products. Lipoxin A4 (LXA4) up-regulates aquaporin 5 (AQP5) and downregulates surfactant protein C but has no effect on receptor for advanced glycation end products. LXA4 promotes AQP5 gene expression while inhibiting surfactant protein C gene expression by primary human alveolar type II (ATII) cells. To determine whether LXA4 can affect AQP5 and surfactant protein C gene expression, ATII cells were treated by LXA4 for 24 h. a) AQP5 gene expression: LXA4 only (2.45±0.65 fold) relative to control group, p=0.004. The effect can be blocked by BOC-2 (formyl peptide receptor antagonist) (LXA4+BOC-2, mean, 0.89±0.12 fold, p=0.007). b) surfactant protein C gene expression: LXA4 only (0.57±0.10 fold) relative to control group, p=0.001. The effect can be blocked by BOC-2 (formyl peptide receptor antagonist) (LXA4+BOC-2, mean, 1.25±0.19 fold, p=0.01). Data are mean±sem of three independent experiments. Shengxing Zheng et al. ERJ Open Res 2016;2:00079-2015 ©2016 by European Respiratory Society