Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia Hiroshi Yazawa, M.D., Isoji Sasagawa, M.D.,

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Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia Hiroshi Yazawa, M.D., Isoji Sasagawa, M.D., Yasuhiro Suzuki, M.D., Teruhiro Nakada, M.D. Fertility and Sterility Volume 75, Issue 5, Pages 980-985 (May 2001) DOI: 10.1016/S0015-0282(01)01705-8

Figure 1 In situ end-labeling of DNA fragmentation of testis section. A, Testis from control rat. In situ end-labeled germ cells were not frequently observed in the seminiferous epithelium (arrows). B, Testis after repair of 90-minute torsion. Labeled cells were frequently found. C, Positivity was mainly observed in spermatogonia (arrowheads) of testis after repair of torsion. D Testis treated with dexamethasone after repair of torsion. The proportion of in situ end-labeled germ cells is smaller than that in a nontreated testis. E, Testis treated with glucocorticoid receptor antagonist after repair of torsion. Germ cells are seriously affected. F, Testis treated with dexamethasone and glucocorticoid-receptor antagonist after repair of torsion. Apoptotic germ cells were frequently found. Magnification ×150 in panels A, B, D, E, and F and ×600 in panel C. Yazawa. Testicular germ cell apoptosis and ischemia. Fertil Steril 2001. Fertility and Sterility 2001 75, 980-985DOI: (10.1016/S0015-0282(01)01705-8)

Figure 2 Neutrophil adhesion to testicular subtunical veins. A, The testis from a control rat had a few neutrophils (arrowheads) adhering to the vein. B, After repair of 90-minute torsion, increasing numbers of neutrophils adhered to the vein (arrowheads). C, Testis treated with dexamethasone after repair of torsion. Neutrophil adhesion in the subtunical vein decreased (arrowheads). All staining was done with hematoxylin and eosin. Magnification ×100 in panel A and ×1,200 in panels B and C. Yazawa. Testicular germ cell apoptosis and ischemia. Fertil Steril 2001. Fertility and Sterility 2001 75, 980-985DOI: (10.1016/S0015-0282(01)01705-8)