Volume 67, Issue 4, Pages (April 2005)

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Volume 67, Issue 4, Pages 1566-1575 (April 2005) Kinetic behavior of urea is different from that of other water-soluble compounds: The case of the guanidino compounds Sunny Eloot, A.N. Torremans, Rita De Smet, Bart Marescau, Dirk De Wachter, Peter Paul De Deyn, Norbert Lameire, Pascal Verdonck, Raymond Vanholder Kidney International Volume 67, Issue 4, Pages 1566-1575 (April 2005) DOI: 10.1111/j.1523-1755.2005.00238.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Flow chart of the two-pool kinetic model. V1, perfused volume; V2, nonperfused volume; Vtot, total distribution volume; C1, concentration in perfused compartment; C2, concentration in nonperfused compartment; CPi, plasma concentration at blood inlet; CPo, plasma concentration at blood outlet; CDi, concentration at dialysate inlet; CDo, concentration at dialysate outlet; K, dialyzer clearance; K12, intercompartmental clearance; GS, solute generation rate; QB, dialyzer blood flow; QD, dialyzer dialysate flow; QUF, ultrafiltration flow. Kidney International 2005 67, 1566-1575DOI: (10.1111/j.1523-1755.2005.00238.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Concentration profiles (mmol/L) during the dialysis session of urea and the different investigated guanidino compounds in a representative patient. The asterisks (*) plot the measured data, while the thin and bold line represents the fitted concentration profiles in the perfused (V1) and nonperfused compartment (V2), respectively. The angle in between the dotted lines is a measure for the solute removed from the nonperfused compartment (delta SC2eff). Kidney International 2005 67, 1566-1575DOI: (10.1111/j.1523-1755.2005.00238.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Correlations between total distribution volume and reduction ratio RR (+), effective reduction, RReff (×), and effective relative concentration decline, delta SC2eff (o). Kidney International 2005 67, 1566-1575DOI: (10.1111/j.1523-1755.2005.00238.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Correlations between solute molecular weight and dialyzer clearance K (+), and intercompartmental clearance K12 (×). Kidney International 2005 67, 1566-1575DOI: (10.1111/j.1523-1755.2005.00238.x) Copyright © 2005 International Society of Nephrology Terms and Conditions