Bioavailable vitamin D in chronic kidney disease

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Presentation transcript:

Bioavailable vitamin D in chronic kidney disease Alex J. Brown, Daniel W. Coyne Kidney International Volume 82, Issue 1, Pages 5-7 (July 2012) DOI: 10.1038/ki.2012.135 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Schematic of a proximal tubular cell demonstrating the role of megalin located in the brush border membrane in reclaiming DBP and any 25(OH)D or 1,25(OH)2D bound to DBP. Heavy proteinuria can lead to substantial DBP losses and potentially contribute to vitamin D deficiency. DBP, vitamin D-binding protein; 1,25(OH)2D, 1,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin D. Kidney International 2012 82, 5-7DOI: (10.1038/ki.2012.135) Copyright © 2012 International Society of Nephrology Terms and Conditions