Reducing inappropriate antibiotic prescribing for children in primary care: a cluster randomised controlled trial of two interventions by Marieke B Lemiengre, Jan Y Verbakel, Roos Colman, Tine De Burghgraeve, Frank Buntinx, Bert Aertgeerts, Frans De Baets, and An De Sutter BJGP Volume 68(668):e204-e210 February 22, 2018 ©2018 by British Journal of General Practice

Flow chart representing the number of acute infectious episodes included in the study. a Scoring positive at one of the following clinical criteria: gut feeling of the physician, presence of dyspnoea, temperature ≥40°C, and diarrhoea in children aged betwee... Flow chart representing the number of acute infectious episodes included in the study.a Scoring positive at one of the following clinical criteria: gut feeling of the physician, presence of dyspnoea, temperature ≥40°C, and diarrhoea in children aged between 1 and 2.5 years. BISNA = brief intervention with safety net. CDR = clinical decision rule. CRP = C-reactive protein. FP = family physician. R = randomisation. UC = usual care. Marieke B Lemiengre et al. Br J Gen Pract 2018;68:e204-e210 ©2018 by British Journal of General Practice

Estimated marginal means of the immediate antibiotic prescribing rate (with 95% confidence interval) for the different intervention groups (adjusted analysis). Estimated marginal means of the immediate antibiotic prescribing rate (with 95% confidence interval) for the different intervention groups (adjusted analysis). BISNA = brief intervention with safety net. CRP = C-reactive protein. UC = usual care. Marieke B Lemiengre et al. Br J Gen Pract 2018;68:e204-e210 ©2018 by British Journal of General Practice