Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain Tarja Heiskanen, MD, PhD, Kaarina Langel, MSc, Teemu Gunnar, BSc, MSc, Pirjo.

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Presentation transcript:

Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain Tarja Heiskanen, MD, PhD, Kaarina Langel, MSc, Teemu Gunnar, BSc, MSc, Pirjo Lillsunde, PhD, Eija A. Kalso, MD, DMedSci Journal of Pain and Symptom Management Volume 50, Issue 4, Pages 524-532 (October 2015) DOI: 10.1016/j.jpainsymman.2014.09.004 Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 1 Flowchart. OF = oral fluid. Journal of Pain and Symptom Management 2015 50, 524-532DOI: (10.1016/j.jpainsymman.2014.09.004) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 2 Variations of opioid doses and plasma opioid concentrations. *Denotes the furthest outlying single measurement values in relation to the mean value of 5 measurements in a patient. Journal of Pain and Symptom Management 2015 50, 524-532DOI: (10.1016/j.jpainsymman.2014.09.004) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 3 Correlations of oral fluid and plasma opioid concentrations. Journal of Pain and Symptom Management 2015 50, 524-532DOI: (10.1016/j.jpainsymman.2014.09.004) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions

Fig. 4 Inter- and intrapatient variation in oral fluid and plasma opioid concentration ratios in patients (N = 29) who gave all five oral fluid and plasma samples over different time points. OF/P = oral fluid/plasma. *Denotes the furthest outlying single measurement values in relation to the mean value of 5 measurements in a patient. Journal of Pain and Symptom Management 2015 50, 524-532DOI: (10.1016/j.jpainsymman.2014.09.004) Copyright © 2015 American Academy of Hospice and Palliative Medicine Terms and Conditions