Volume 72, Issue 7, Pages (October 2007)

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Volume 72, Issue 7, Pages 865-870 (October 2007) Spot urine protein/creatinine ratios are unreliable estimates of 24 h proteinuria in most systemic lupus erythematosus nephritis flares D.J. Birmingham, B.H. Rovin, G. Shidham, H.N. Nagaraja, X. Zou, M. Bissell, C.-Y. Yu, L.A. Hebert Kidney International Volume 72, Issue 7, Pages 865-870 (October 2007) DOI: 10.1038/sj.ki.5002421 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Intended 24-h urine collections that are greater than 50% complete provide p/c ratios comparable to that of complete 24-h urine collections. (a) The relationship between M/E ratio and 24-h urine P/C ratio for each of the 645 individual 24-h collections of the OSS patients. These values are shown in relationship to the mean 24-h P/C ratio (horizontal line). No relationship between M/E ratio and P/C ratio was found. (P=0.11). (b) Individual mean 24-h urine P/C ratios by M/E ratio group are shown. No differences were found among the P/C ratios of the four M/E ratio categories (P=0.11). Kidney International 2007 72, 865-870DOI: (10.1038/sj.ki.5002421) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Spot urine P/C ratio is a poor predictor of 24-h urine P/C ratio particularly if the latter is less than 3.0. (a) The relationship between 24-h urine P/C ratio and the paired spot urine P/C ratio, in the 24-h urine P/C ratio range of 0.5–3.0. This analysis involves 24-h urine collections with M/E ratios ≥0.75. The association was significant (r=0.529, P=0.0013), but concordance was weak (CCC=0.479). (b) The relationship between the ratio (spot urine P/C ratio/24 h urine P/C ratio) and the 24-h urine P/C ratio. This analysis includes the cohort with M/E ratios between 0.5 and <0.75 (open circles) and the cohort with M/E ratios ≥0.75 (filled circles), over the entire range of the 24-h urine P/C ratios in this study. Kidney International 2007 72, 865-870DOI: (10.1038/sj.ki.5002421) Copyright © 2007 International Society of Nephrology Terms and Conditions