An Argonaute Protein Directs Nuclear Xrn2 Function

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An Argonaute Protein Directs Nuclear Xrn2 Function Daniele Hasler, Gunter Meister Molecular Cell Volume 48, Issue 4, Pages 485-486 (November 2012) DOI: 10.1016/j.molcel.2012.11.015 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Twi12 Directs Xrn2 Exonuclease to the Nucleus and Stimulates Its Activity Upon loading with tRNA 3′ fragments (red), Twi12 forms a complex with Xrn2 and Tan1 (TXT). The exonucleolytic activity of Xrn2 and TXT import into the macronucleus depend on the association with Twi12. In the nucleus, Xrn2 (possibly as part of TXT) is involved in various RNA processing and degradation pathways. Molecular Cell 2012 48, 485-486DOI: (10.1016/j.molcel.2012.11.015) Copyright © 2012 Elsevier Inc. Terms and Conditions