Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction Shigetoshi.

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Presentation transcript:

Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction Shigetoshi Mieno, MD, Hitoshi Horimoto, MD, PhD, Fusao Watanabe, PhD, Yasunari Nakai, MD, PhD, Eisuke Furuya, PhD, Shinjiro Sasaki, MD, PhD The Annals of Thoracic Surgery Volume 74, Issue 4, Pages 1213-1218 (October 2002) DOI: 10.1016/S0003-4975(02)03841-9

Fig 1 Langendorff perfusion protocol for the six groups. Global ischemia occurred from 0 to 20 min and reperfusion from 20 to 140 min. Group 1: designated control hearts (sham operation); group 2: ischemic preconditioning (IPC) in sham hearts; group 3: post-myocardial infarction (MI) hearts; group 4: IPC in post-MI hearts; group 5: forskolin infusion in post-MI hearts; group 6: combined forskolin infusion and ischemic preconditioning in post-MI hearts. The Annals of Thoracic Surgery 2002 74, 1213-1218DOI: (10.1016/S0003-4975(02)03841-9)

Fig 2 Left ventricular peak developed pressure during the experiment. Peak developed pressure was defined as the difference between end-systolic pressure and end-diastolic pressure. Ischemic preconditioning or drug infusion was performed before 0 on the timeline. Global ischemia occurred from 0 to 20 min and reperfusion from 20 to 140 min. Data are shown as mean ± standard deviation. Group 1: designated control hearts (sham operation); group 2: ischemic preconditioning (IPC) in sham hearts; group 3: post-myocardial infarction (MI) hearts; group 4: IPC in post-MI hearts; group 5: forskolin infusion in post-MI hearts; group 6: combined forskolin infusion and ischemic preconditioning in post-MI hearts. The Annals of Thoracic Surgery 2002 74, 1213-1218DOI: (10.1016/S0003-4975(02)03841-9)

Fig 3 Infarct size in the six groups, as determined by triphenyltetrazolium chloride staining of the left ventricle area at risk. Group 1: designated control hearts (sham operation); group 2: ischemic preconditioning (IPC) in sham hearts; group 3: post-myocardial infarction (MI) hearts; group 4: IPC in post-MI hearts; group 5: forskolin infusion in post-MI hearts; group 6: combined forskolin infusion and ischemic preconditioning in post-MI hearts. Bars indicate mean ± standard deviation. ∗p < 0.05 vs group 1; ∗∗p < 0.05 vs group 4; #p < 0.05 vs group 5. The Annals of Thoracic Surgery 2002 74, 1213-1218DOI: (10.1016/S0003-4975(02)03841-9)