Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction  Shigetoshi.

Slides:



Advertisements
Similar presentations
Morphologic Spectrum of Ventriculoarterial Connection in Hearts With Double Inlet Left Ventricle: Implications for Surgical Procedures Hideki Uemura, MD,
Advertisements

Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow  Patrick E Parrino, MD, Victor E Laubach, PhD, John R.
Fig. 2. Post-treatment with isoflurane reduced infarct volume
Runar Lundblad, MD, Michel Abdelnoor, PhD, Jan L Svennevig, MD 
Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat  Ryuzo Bessho, MD, PhD, David J. Chambers,
Reduction of systolic and diastolic dysfunction by retrograde coronary sinus perfusion during off-pump coronary surgery  Manuel Castellá, MD, Gerald D.
Coronary Artery Bypass for Heart Failure in Ischemic Cardiomyopathy: 17-Year Follow- Up  Marco Pocar, MD, PhD, Andrea Moneta, MD, Adalberto Grossi, MD,
Celsior versus custodiol: early postischemic recovery after cardioplegia and ischemia at 5°C  Juergen Ackemann, MD, Wolfgang Gross, PhD, Martin Mory,
Cardiomyocyte Transplantation Improves Heart Function
A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion.
Runar Lundblad, MD, Michel Abdelnoor, PhD, Jan L Svennevig, MD 
Functional evaluation of human donation after cardiac death donor hearts using a continuous isolated myocardial perfusion technique: Potential for expansion.
Failure of Preconditioning to Improve Postcardioplegia Stunning of Minimally Infarcted Hearts  Bouchaib Faris, Jacqueline Peynet, Michel Wassef, Alain.
Preconditioning protects the severely atherosclerotic mouse heart
Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach  Michael T. Kronon,
Nitric oxide–generating β-adrenergic blocker nipradilol preserves postischemic cardiac function  Hitoshi Horimoto, MD, Adam E Saltman, MD, PhD, Glenn.
Hyperdynamic circulation of arteriovenous fistula preconditions the heart and limits infarct size  Mahmoud A Mahgoub, MD, Jian-Hau Guo, MD, Shi-Ping Gao,
Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac.
Ventricular septal rupture caused by myocardial bridging
Calcium-Channel Blockers Preserve Coronary Endothelial Reactivity After Ischemia- Reperfusion  François Dagenais, MD, Raymond Cartier, MD, Charleen Hollmann,
Autologous smooth muscle cell transplantation improved heart function in dilated cardiomyopathy  Kyung-Jong Yoo, MD, Ren-Ke Li, MD, PhD, Richard D. Weisel,
Long-term exposure to high altitude hypoxia during pregnancy increases fetal heart susceptibility to ischemia/reperfusion injury and cardiac dysfunction 
Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J
Heike A. Hildebrandt et al. BTS 2016;1:3-13
Increased susceptibility of hypertrophied hearts to ischemic injury
Proteasome Inhibition Attenuates Infarct Size and Preserves Cardiac Function in a Murine Model of Myocardial Ischemia-Reperfusion Injury  William E. Stansfield,
Prolonged preservation of the blood-perfused canine heart with glycolysis-promoting solution  Koh Takeuchi, MD, Hung Cao-Danh, PhD, Akihiko Kawai, MD,
Long-term treatment with nipradilol, a nitric oxide–releasing β-adrenergic blocker, enhances postischemic recovery and limits infarct size  Yoshihiro.
Hirotsugu Hamamoto, MD, Bradley G. Leshnower, MD, Landi M
John Alfred Carr, MD, Joseph J. Amato, MD, Robert S.D. Higgins, MD 
Opioid preconditioning: myocardial function and energy metabolism
Effects of cardioplegia on vascular function and the “no-reflow" phenomenon after ischemia and reperfusion: Studies in the isolated blood-perfused rat.
LV-powered coronary sinus retroperfusion reduces infarct size in acutely ischemic pigs  Jeffrey S Martin, MD, John G Byrne, MD, Olivier Y Ghez, MD, Umer.
J. Trent Magruder, MD, Todd C
The Contribution of Na/H Exchange to Ischemia-Reperfusion Injury After Hypothermic Cardioplegic Arrest  Takashi Yamauchi, MD, Hajime Ichikawa, MD, Yoshiki.
Coronary Microvascular Reactivity After Ischemic Cold Storage and Reperfusion  Charles O Murphy, MD, Pan- Chih, MD, John Parker Gott, MD, Robert A Guyton,
Bradykinin pretreatment improves ischemia tolerance of the rabbit heart by tyrosine kinase mediated pathways  Jun Feng, MD, PhD, Eliot R Rosenkranz, MD 
Roland L Featherstone, PhD, David J Chambers, PhD, Frank J Kelly, PhD 
Repair of aortic coarctation in patients more than 50 years of age
Induction of the expression of cardioprotective proteins after mild-to-moderate consumption of alcohol  Motoaki Sato, Cesar Fraga, Dipak K. Das  Pathophysiology 
Periostin Is a Novel Factor in Cardiac Remodeling After Experimental and Clinical Unloading of the Failing Heart  William E. Stansfield, MD, Nancy M.
Organ perfusion with hemopump device assistance with and without intraaortic balloon pumping  Bart Meyns, MD, Yousuke Nishimura, MD, Rozalia Racz, MD,
Dysfunction induced by ischemia versus edema: Does edema matter?
Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.
Ischemic preconditioning ameliorates spinal cord ischemia-reperfusion injury by triggering autoregulation  Cheng-Loong Liang, MD, Kang Lu, MD, PhD, Po-Chou.
Elimination of Ischemic Mitral Regurgitation Does Not Alter Long-Term Left Ventricular Remodeling in the Ovine Model  Kanji Matsuzaki, MD, PhD, Masato.
Gregory A Thomas, MD, Larry W Stephenson, MD 
Near-infrared monitoring of myocardial oxygenation during ischemic preconditioning  Michio Kawasuji, MD, Masahiro Ikeda, MD, Naoki Sakakibara, MD, Susumu.
Beneficial effects of ischemic preconditioning on right ventricular function after coronary artery bypass grafting  Zhong-Kai Wu, MD, Matti R Tarkka,
Reactive hyperemia during early reperfusion as a determinant of improved functional recovery in ischemic preconditioned rat hearts  Annie Rochetaing,
Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia  James D McCully, PhD, Masahisa Uematsu,
Evan Loh, MD, Edward B. Lankford, MD, PhD, David J
Heat shock improves recovery and provides protection against global ischemia after hypothermic storage  Ashok Gowda, MS, Chunjie Yang, MD, Gregory K Asimakis,
In Vivo Fluorometric Assessment of Cyclosporine on Mitochondrial Function During Myocardial Ischemia and Reperfusion  Muneaki Matsubara, MD, Mahsa Ranji,
Age- and Gender-Related Differences in Mitochondrial Oxygen Consumption and Calcium With Cardioplegia and Diazoxide  James D. McCully, PhD, Anthony J.
Effects of an Angiotensin II Antagonist on Ischemic and Nonischemic Isolated Rat Hearts  Yosef Paz, Jacob Gurevitch, Inna Frolkis, Menachem Matsa, Amir.
Preoperative risk factors for right ventricular failure after implantable left ventricular assist device insertion  Kiyotaka Fukamachi, MD, PhD, Patrick.
Richard Lee, Takashi Nitta, Ralph A. Schmid, Richard B
James E. Davies, MD, Stanley B. Digerness, PhD, Cheryl R
Ascending versus descending aortic balloon
Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor  Yuka Uchiyama,
Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia  Manuel Galiñanes, MD, PhD, Ryszard.
Myocardial protection by ischemic preconditioning and δ-opioid receptor activation in the isolated working rat heart  Matthias Karck, MDa, Satonori Tanaka,
Andrew D Cochrane, Shobhna Pathik, Joseph J Smolich, Robert A
Impact of Surgical Ventricular Restoration on Diastolic Function: Implications of Shape and Residual Ventricular Size  Serenella Castelvecchio, MD, Lorenzo.
Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart  Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi.
Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations  Alain Bel, MD, Louis P Perrault, MD, PhD, Bouchaib Faris,
Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites  Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.
Renato Faro, PhD, Yoshiya Toyoda, MD, James D
Left Ventricular End-Diastolic Pressure Predicts Survival in Coronary Artery Bypass Graft Surgery Patients  Jeevan Nagendran, MD, PhD, Colleen M. Norris,
Presentation transcript:

Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction  Shigetoshi Mieno, MD, Hitoshi Horimoto, MD, PhD, Fusao Watanabe, PhD, Yasunari Nakai, MD, PhD, Eisuke Furuya, PhD, Shinjiro Sasaki, MD, PhD  The Annals of Thoracic Surgery  Volume 74, Issue 4, Pages 1213-1218 (October 2002) DOI: 10.1016/S0003-4975(02)03841-9

Fig 1 Langendorff perfusion protocol for the six groups. Global ischemia occurred from 0 to 20 min and reperfusion from 20 to 140 min. Group 1: designated control hearts (sham operation); group 2: ischemic preconditioning (IPC) in sham hearts; group 3: post-myocardial infarction (MI) hearts; group 4: IPC in post-MI hearts; group 5: forskolin infusion in post-MI hearts; group 6: combined forskolin infusion and ischemic preconditioning in post-MI hearts. The Annals of Thoracic Surgery 2002 74, 1213-1218DOI: (10.1016/S0003-4975(02)03841-9)

Fig 2 Left ventricular peak developed pressure during the experiment. Peak developed pressure was defined as the difference between end-systolic pressure and end-diastolic pressure. Ischemic preconditioning or drug infusion was performed before 0 on the timeline. Global ischemia occurred from 0 to 20 min and reperfusion from 20 to 140 min. Data are shown as mean ± standard deviation. Group 1: designated control hearts (sham operation); group 2: ischemic preconditioning (IPC) in sham hearts; group 3: post-myocardial infarction (MI) hearts; group 4: IPC in post-MI hearts; group 5: forskolin infusion in post-MI hearts; group 6: combined forskolin infusion and ischemic preconditioning in post-MI hearts. The Annals of Thoracic Surgery 2002 74, 1213-1218DOI: (10.1016/S0003-4975(02)03841-9)

Fig 3 Infarct size in the six groups, as determined by triphenyltetrazolium chloride staining of the left ventricle area at risk. Group 1: designated control hearts (sham operation); group 2: ischemic preconditioning (IPC) in sham hearts; group 3: post-myocardial infarction (MI) hearts; group 4: IPC in post-MI hearts; group 5: forskolin infusion in post-MI hearts; group 6: combined forskolin infusion and ischemic preconditioning in post-MI hearts. Bars indicate mean ± standard deviation. ∗p < 0.05 vs group 1; ∗∗p < 0.05 vs group 4; #p < 0.05 vs group 5. The Annals of Thoracic Surgery 2002 74, 1213-1218DOI: (10.1016/S0003-4975(02)03841-9)