Evidence for a true post-β-lactamase-inhibitor effect of clavulanic acid against Klebsiella pneumoniae and Haemophilus influenzae  V. Murbach, N. Dhoyen,

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Evidence for a true post-β-lactamase-inhibitor effect of clavulanic acid against Klebsiella pneumoniae and Haemophilus influenzae  V. Murbach, N. Dhoyen, L. Linger, H. Monteil, F. Jehl  Clinical Microbiology and Infection  Volume 7, Issue 12, Pages 661-665 (December 2001) DOI: 10.1046/j.1469-0691.2001.00336.x Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 General technical procedures investigating each of the effects studied: AMC, amoxicillin + clavulanic acid (2 mg/L); CA, clavulanic acid; AMX, amoxicillin; PAE, post-antibiotic effect; PLIE, post-β-lactamase-inhibitor effect; DG, delay in growth. Clinical Microbiology and Infection 2001 7, 661-665DOI: (10.1046/j.1469-0691.2001.00336.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Evidence for PLIE after CA or AMX/CA exposure against H. influenzae: CA 1, clavulanic acid 1 mg/L; AMX 8, amoxicillin 8 mg/L; AMC 8/2, amoxicillin 8 mg/L + clavulanic acid 2 mg/L; PLIE, post-β-lactamase-inhibitor effect. Clinical Microbiology and Infection 2001 7, 661-665DOI: (10.1046/j.1469-0691.2001.00336.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

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