Effects of long-term estrogen replacement therapy on articular cartilage IGFBP-2, IGFBP-3, collagen and proteoglycan levels in ovariectomized cynomolgus.

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Effects of long-term estrogen replacement therapy on articular cartilage IGFBP-2, IGFBP-3, collagen and proteoglycan levels in ovariectomized cynomolgus.

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Effects of long-term estrogen replacement therapy on articular cartilage IGFBP-2, IGFBP-3, collagen and proteoglycan levels in ovariectomized cynomolgus monkeys K.D Ham, B.A., T.R Oegema, Ph.D., R.F Loeser, M.D., C.S Carlson, D.V.M., Ph.D. Osteoarthritis and Cartilage Volume 12, Issue 2, Pages 160-168 (February 2004) DOI: 10.1016/j.joca.2003.08.002

Fig. 1 Desorption levels of IGFBP-3 (a), IGFBP-2 (b), and total protein (c) per mg of monkey cartilage from animals in the three treatment groups. Bars represent the mean and standard error, and ∗∗ indicates significantly different from control (P<0.05). Results represent the total of all three desorptions. Soy, soy phytoestrogen. Osteoarthritis and Cartilage 2004 12, 160-168DOI: (10.1016/j.joca.2003.08.002)

Fig. 2 Articular cartilage sections from monkey tibial plateaus, stained for IGFBPs using immunohistochemistry. Positive immunostaining for IGFBP-2 and IGFBP-3 is reddish-brown (a, b), positive immunostaining for IGFBP-1 is pink (c), and counterstained cells are blue. IGFBP-2 staining showed specific pericellular (closed arrow) and cellular (open arrows) staining throughout the articular cartilage (a). Staining for IGFBP-3 revealed cellular staining throughout the cartilage, including the deep zones (arrows) (b). Staining for IGFBP-1 revealed superficial cartilage matrix staining (arrows) (c). Negative control (d). Tissues are from estrogen-treated (a, b), control group (c) and soy phytoestrogen-treated (d) animals. Osteoarthritis and Cartilage 2004 12, 160-168DOI: (10.1016/j.joca.2003.08.002)