Improving therapy outcome prediction in major depression using multimodal functional neuroimaging: A pilot study  Johannes Schultz, Benjamin Becker, Katrin Preckel, Meike Seifert, Clemens Mielacher, Rupert Conrad, Alexandra Kleiman, Wolfgang Maier, Keith M. Kendrick, René Hurlemann  Personalized Medicine in Psychiatry   Volume 11, Pages 7-15 (November 2018) DOI: 10.1016/j.pmip.2018.09.001 Copyright © 2018 Elsevier Inc. Terms and Conditions

Fig. 1 Abnormal neural response to emotional faces in MDD. A: left inferior and middle frontal gyrus, precuneus and right posterior middle temporal sulcus show decreased (green, blue circles) and right postcentral gyrus shows increased (yellow, red circles) BOLD responses during presentation of emotional faces compared to neutral faces, in patients pre-treatment compared to both patients post-treatment and controls (conjunction contrast). Results are shown here rendered on the average structural scan of all participants, and are thresholded at p < 0.05 corrected for family-wise errors (FWE) resulting from multiple comparisons across all voxels of the brain. X and Z values indicate the position of the slice in MNI coordinate space. B: Left amygdala showed an increased response to emotional compared to neutral faces in MDD pre-treatment compared with controls; this response decreased after therapy. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Personalized Medicine in Psychiatry  2018 11, 7-15DOI: (10.1016/j.pmip.2018.09.001) Copyright © 2018 Elsevier Inc. Terms and Conditions

Fig. 2 Results of resting-state functional connectivity analyses. A: Before treatment, patients showed a reduced resting-state functional connectivity between the right subgenual cingulate (sgACC) and the right middle frontal gyrus compared with healthy controls (conventions as in Fig. 1). B: Therapy resulted in a reduction of resting-state connectivity between seeds in right dorsolateral prefrontal cortex and right intraparietal sulcus in patients. Red dots are projections on the right hemispheric surface of the location of connectivity seeds included in the analysis. IPS = intraparietal sulcus; dACC = dorsal anterior cingulate cortex; DLPFC = dorsolateral prefrontal cortex; MPFC = medial prefrontal cortex; AI = anterior insula; sgACC = subgenual anterior cingulate cortex; AMY = amygdala. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Personalized Medicine in Psychiatry  2018 11, 7-15DOI: (10.1016/j.pmip.2018.09.001) Copyright © 2018 Elsevier Inc. Terms and Conditions