Curbing Fear by Axonal Oxytocin Release in the Amygdala

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Curbing Fear by Axonal Oxytocin Release in the Amygdala Philip Tovote, Andreas Lüthi Neuron Volume 73, Issue 3, Pages 407-410 (February 2012) DOI: 10.1016/j.neuron.2012.01.016 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Identifying a Microcircuit of OT-Mediated Fear Attenuation within the Central Amygdala using Optogenetics Paraventricular (PVN), supraoptic (SON), and accessory magnocellular (AN) hypothalamic nuclei send projections of varying strength (indicated by red line thickness) to the central amydala (CeA). Light activation of channelrhodopsin-2-expressing OT axon terminals in the lateral division of CeA (CeL) results in local release of OT (dark blue circles), causing enhanced activity of inhibitory CeL cells (light blue) that project to the medial division of CeA (CeM). Increased inhibition of CeM output cells (green) leads to attenuation of fear. Neuron 2012 73, 407-410DOI: (10.1016/j.neuron.2012.01.016) Copyright © 2012 Elsevier Inc. Terms and Conditions