Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells Homologous recombination deficiency scores.

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Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells Homologous recombination deficiency scores correlate with drug‐induced cell death in primary ovarian cancer cells AVisualization of homologous recombination deficiency (HRD) score determination by counting lost chromosome regions. Total copy number (TCN) and B‐allele frequency (BAF) plots derived from Asc15 whole‐genome sequencing data are shown. Black squares illustrate chromosome regions summarized as HRD score.BHRD scores of patient‐derived ovarian cancer cell lines used for DeathPro drug screening.CHeat map of correlation coefficients (R2) and estimated false discovery rates (FDR) determined from systematic association of drug responses (AUCd: cell death, AUCpi: growth arrest) with HRD scores. FDR was estimated by random sampling.D–HDrug‐induced cell death (AUCd) or growth arrest (AUCpi) of all nine primary OC cell lines divided into two groups with low (< 10) or high (≥ 10) HRD score. Cytotoxicity induced by carboplatin (D), paclitaxel (E), azacytidine (F) and decitabine (G) correlates with HRD score. Growth arrest induced by temsirolimus (H) is reduced in HR deficient cells. R² values of not significant correlations are shown in italics. Data information: *P < 0.05 in two‐sided Welch's t‐test. Julia Jabs et al. Mol Syst Biol 2017;13:955 © as stated in the article, figure or figure legend