AOPPs and the progression of kidney disease

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Presentation transcript:

AOPPs and the progression of kidney disease Wei Cao, Fan Fan Hou, Jing Nie Kidney International Supplements Volume 4, Issue 1, Pages 102-106 (November 2014) DOI: 10.1038/kisup.2014.19 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Renal accumulation of advanced oxidation protein products (AOPPs) in IgA nephropathy. AOPPs were detected predominantly in tubular epithelial cells, podocytes, and mesangial cells, and in some cases, in arterial/arteriolar endothelial cells and interstitial infiltrating cells. Kidney International Supplements 2014 4, 102-106DOI: (10.1038/kisup.2014.19) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Schematic diagram summarizing the pathogenic role of advanced oxidation protein products (AOPPs) in the progression of chronic kidney disease (CKD). Chronic accumulation of AOPPs in CKD, through its interaction with RAGE or CD36, triggers a cascade of signaling events that lead to protein kinase C/NAD(P)H oxidase activation, superoxide (O2−) generation, NF-κB, AP-1 activation, and finally podocyte apoptosis, mesangial cell ECM overproduction, vascular endothelial cell inflammation, and tubular RAS activation. Kidney International Supplements 2014 4, 102-106DOI: (10.1038/kisup.2014.19) Copyright © 2014 International Society of Nephrology Terms and Conditions