Pregnancy-associated plasma protein A in human ovarian follicles and its association with intrafollicular hormone levels Jane Alrø Bøtkjær, M.Sc., Janni.

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Presentation transcript:

Pregnancy-associated plasma protein A in human ovarian follicles and its association with intrafollicular hormone levels Jane Alrø Bøtkjær, M.Sc., Janni Vikkelsø Jeppesen, Ph.D., Marie Louise Wissing, Ph.D., Søren Kløverpris, Ph.D., Claus Oxvig, D.M.Sc., J. Ian Mason, Ph.D., Tanni Borgbo, Ph.D., Claus Yding Andersen, D.M.Sc. Fertility and Sterility Volume 104, Issue 5, Pages 1294-1301.e1 (November 2015) DOI: 10.1016/j.fertnstert.2015.07.1152 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Intrafollicular levels of pregnancy-associated plasma protein A (PAPP-A) in relation to ovarian hormones: (A) antimüllerian hormone (AMH) vs. PAPP-A, (B) E2 vs. PAPP-A, (C) P vs. PAPP-A, (D) T vs. PAPP-A, (E) A vs. PAPP-A, and (F) AMH vs. E2. White triangles: small human antral follicles; gray squares: follicles collected before the LH surge; black diamonds: follicles collected after the LH surge from women stimulated with recombinant FSH. Fertility and Sterility 2015 104, 1294-1301.e1DOI: (10.1016/j.fertnstert.2015.07.1152) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 The proteolytic activity of pregnancy-associated plasma protein A (PAPP-A) toward insulin-like growth factor–binding protein 4 (IGFBP-4) in follicular fluid (FF) in the presence or absence of 1 μmol/L of an inhibitory monoclonal antibody specific for PAPP-A (mAb 1/41) or a control IgG. As control samples, IGFBP-4 was incubated with or without (Mock) 35 pmol/L recombinant PAPP-A (rPAPP-A). Cleavage reactions were stopped after 4 hours. Fertility and Sterility 2015 104, 1294-1301.e1DOI: (10.1016/j.fertnstert.2015.07.1152) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Immunoexpression of PAPP-A, AMH, and CYP19 aromatase. Small antral follicles (5–6 mm in diameter): A, D, G, and J; large antral follicles (8–9 mm in diameter): B, b, E, e, H, h, K, k; and preovulatory human antral follicles: C, F, I, and L. GC = granulosa cells; TC = theca cells; other abbreviations as in Figure 1. Scale bars: 50 μm (A, B, D, E, G, H, J, and K) or 20 μm (b, C, e, F, h, I, k, and L). Fertility and Sterility 2015 104, 1294-1301.e1DOI: (10.1016/j.fertnstert.2015.07.1152) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Immunoexpression of CYP19 aromatase in a 9 mm antral follicle. Abbreviations as in Figures 2 and 3. For control staining, see Figure 2. Scale bar = 50 μm. Fertility and Sterility 2015 104, 1294-1301.e1DOI: (10.1016/j.fertnstert.2015.07.1152) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions