Development and testing of Streptococcus pneumoniae conjugate vaccines

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Presentation transcript:

Development and testing of Streptococcus pneumoniae conjugate vaccines David L. Klein, Juhani Eskola Clinical Microbiology and Infection Volume 5, Pages 4S17-4S28 (August 1999) DOI: 10.1111/j.1469-0691.1999.tb00853.x Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Ratio of GMCs (conjugate/PS) after pneumococcal vaccination in healthy adults: C/P, conjugate vaccine/polysaccharide vaccine ratio; GMC, geometric mean concentration; PS, polysaccharide; PncCRM, five-component pneumococcal oligosaccharide conjugate with CRM 197 protein carrier (Wyeth Lederle); PncOMPC, pneumococcal conjugate with outer-membrane protein complex carrier (Merck Research Laboratories); PnCD, pneumococcal conjugate with diphtheria carrier (Pasteur/Merieux/Connaught); PnCRM, seven-component pneumococcal conjugate with CRM 197 protein carrier (Wyeth-Lederle) [24,27]. Clinical Microbiology and Infection 1999 5, 4S17-4S28DOI: (10.1111/j.1469-0691.1999.tb00853.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Increase in avidity of antibodies after booster vaccination: PncD, PMC pneumococcal conjugate vaccine; PncPS, 23-valent pneumococcal polysaccharide vaccine [29]. Clinical Microbiology and Infection 1999 5, 4S17-4S28DOI: (10.1111/j.1469-0691.1999.tb00853.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 3 Response to 23-valent pneumococcal polysaccharide vaccine (PncPS) or Wyeth-Lederle pneumococcal conjugate vaccine (PncCRM) in children with recurrent infections [32]. Clinical Microbiology and Infection 1999 5, 4S17-4S28DOI: (10.1111/j.1469-0691.1999.tb00853.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 4 Pneumococcal carriage after PncCRM in Israeli toddlers: PncCRM, Wyeth-Lederle pneumococcal conjugate vaccine; Pnc, pneumococci; VT Pnc, vaccine-type pneumococci; Pen-R, penicillin-resistant types; MDR, multiresistant; Control, meningococcal C conjugate vaccine [35]. Clinical Microbiology and Infection 1999 5, 4S17-4S28DOI: (10.1111/j.1469-0691.1999.tb00853.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 5 Reduction of pharyngeal carriage after PncCRM vaccination in infancy; PncCRM, Wyeth-Lederle pneumococcal conjugate vaccine; Placebo, meningococcal C conjugate vaccine; VT, vaccine types; Others, non-vaccine serotypes [36]. Clinical Microbiology and Infection 1999 5, 4S17-4S28DOI: (10.1111/j.1469-0691.1999.tb00853.x) Copyright © 1999 European Society of Clinical Infectious Diseases Terms and Conditions