Judy Nee, Mohammed Zakari, Michael A

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Presentation transcript:

Efficacy of Treatments for Opioid-Induced Constipation: Systematic Review and Meta- analysis Judy Nee, Mohammed Zakari, Michael A. Sugarman, Julia Whelan, William Hirsch, Shahnaz Sultan, Sarah Ballou, Johanna Iturrino, Anthony Lembo Clinical Gastroenterology and Hepatology Volume 16, Issue 10, Pages 1569-1584.e2 (October 2018) DOI: 10.1016/j.cgh.2018.01.021 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 PRISMA flow diagram of studies identified, excluded, and finally included for the meta-analysis. Clinical Gastroenterology and Hepatology 2018 16, 1569-1584.e2DOI: (10.1016/j.cgh.2018.01.021) Copyright © 2018 AGA Institute Terms and Conditions

Figure 2 Funnel plot for all studies included in the analysis. Negative log relative risk values represent studies with superior efficacy for the drug compared to placebo. Clinical Gastroenterology and Hepatology 2018 16, 1569-1584.e2DOI: (10.1016/j.cgh.2018.01.021) Copyright © 2018 AGA Institute Terms and Conditions

Figure 3 Forest plot demonstrating the efficacy of all drugs compared to placebo. The relative risk with 95% CI is displayed for the risk of failure to respond to treatment to drug (“Events”) compared to placebo. Values below one represent a favorable result for drug treatment. Clinical Gastroenterology and Hepatology 2018 16, 1569-1584.e2DOI: (10.1016/j.cgh.2018.01.021) Copyright © 2018 AGA Institute Terms and Conditions