Feasibility of Macrophage Plaque Imaging Using Novel Ultrasmall Superparamagnetic Iron Oxide in Dual Energy CT Hideyuki Sato, Shinichiro Fujimoto, Yosuke.

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Feasibility of Macrophage Plaque Imaging Using Novel Ultrasmall Superparamagnetic Iron Oxide in Dual Energy CT Hideyuki Sato, Shinichiro Fujimoto, Yosuke Kogure, Hiroyuki Daida European Journal of Radiology Open Volume 5, Pages 87-91 (January 2018) DOI: 10.1016/j.ejro.2018.05.003 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Composition of Carboxymethyl-diethylaminoethyl Dextran Magnetite USPIO. USPIO: Ultrasmall Superparamagnetic Iron Oxide. European Journal of Radiology Open 2018 5, 87-91DOI: (10.1016/j.ejro.2018.05.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Dilute contrast medium phantom. European Journal of Radiology Open 2018 5, 87-91DOI: (10.1016/j.ejro.2018.05.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Simulated vascular phantom. A simulated vascular phantomdivided into 4 layers (meat alone, meat + Carboxymethyl-diethylaminoethyl Dextran Magnetite USPIO, vascular lumen, and with or without calcification) was prepared, placed in an acrylic phantom. The iron concentration in Carboxymethyl-diethylaminoethyl Dextran Magnetite USPIO was set to 3 steps: 5, 25, and 50 mg/mL. USPIO: Ultrasmall Superparamagnetic Iron Oxide. European Journal of Radiology Open 2018 5, 87-91DOI: (10.1016/j.ejro.2018.05.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 4 Method of overlay map of VMI and MDI. We displayed the color map at 2.5 mgFe/ml intervalsVMI: Virtual Monochromatic Imaging, MDI: Material Density Imaging. European Journal of Radiology Open 2018 5, 87-91DOI: (10.1016/j.ejro.2018.05.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 5 Over lay map of VMI and MDI in simulated vascular phantom. (a) The iron concentration was 5mgFe/ml, without calcification (HAP), (b) The iron concentration was 25mgFe/ml, without calcification (HAP), (c) The iron concentration was 50mgFe/ml, without calcification (HAP), (d) The iron concentration was 5mgFe/ml, with calcification (HAP), (e) The iron concentration was 25mgFe/ml, with calcification (HAP), (d) The iron concentration was 50mgFe/ml, with calcification (HAP). The presence of calcification in the lesion did not influence the findings (a < b < c, d < e < f). VMI: Virtual Monochromatic Imaging, MDI: Material Density Imaging. European Journal of Radiology Open 2018 5, 87-91DOI: (10.1016/j.ejro.2018.05.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 6 Simulate vascular phantom filled with iodine contrast medium. Influence of the iodine contrast medium on Carboxymethyl-diethylaminoethyl Dextran Magnetite USPIO accumulation was not shown. USPIO: Ultrasmall Superparamagnetic Iron Oxide. European Journal of Radiology Open 2018 5, 87-91DOI: (10.1016/j.ejro.2018.05.003) Copyright © 2018 The Authors Terms and Conditions