Volume 114, Issue 1, Pages 123-129 (January 1998) Hydrolysis of dietary fat by pancreatic lipase stimulates cholecystokinin release  Pius Hildebrand, Christophe Petrig, Beat Burckhardt, Silvia Ketterer, Hans Lengsfeld, André Fleury, Paul Hadváry, Christoph Beglinger  Gastroenterology  Volume 114, Issue 1, Pages 123-129 (January 1998) DOI: 10.1016/S0016-5085(98)70640-7 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 Effects of saline (control; ○) or increasing doses of THL on meal-stimulated lipase outputs in 10 healthy volunteers. THL dose-dependently inhibits intraduodenal lipase activity; with the highest dose (120 mg; ■), lipase outputs are below premeal values. ●, 30 mg THL; ▴, 60 mg THL. Postprandial lipase activity was significantly suppressed by all doses of THL (P < 0.05-0.01, respectively). Data are mean ± SEM. Gastroenterology 1998 114, 123-129DOI: (10.1016/S0016-5085(98)70640-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Effect of saline (control; ○) or increasing concentrations of THL on the hydrolysis of dietary triglycerides, monitored by the intraduodenal appearance of C11-acyl FFAs in 10 healthy volunteers. The highest dose of THL (120 mg; ■) virtually abolished appearance of intraduodenal FFAs. ●, 30 mg THL; ▴, 60 mg THL. Appearance of free fatty acids at the ligament of Treitz was significantly reduced by all doses of THL (P < 0.01, respectively). Data are expressed as percentage of totally administered glycerol-bound fatty acids. Gastroenterology 1998 114, 123-129DOI: (10.1016/S0016-5085(98)70640-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 3 Meal-stimulated exocrine pancreatic secretion (A, amylase output; B, trypsin output; and C, lipase protein output) without (control; ○) or with THL (120 mg; ■) in 10 healthy volunteers. Postprandial enzyme secretions were significantly (P < 0.05, respectively) inhibited by THL-mediated inhibition of hydrolysis of dietary triglycerides and plasma CCK release. Data are mean ± SEM. Gastroenterology 1998 114, 123-129DOI: (10.1016/S0016-5085(98)70640-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 4 Effect of saline (control; ○) or THL (120 mg; ■) on mealstimulated bilirubin output in 10 healthy volunteers. THL eliminated postprandial biliary response (P < 0.01). Data are mean ± SEM. Gastroenterology 1998 114, 123-129DOI: (10.1016/S0016-5085(98)70640-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 5 Effect of saline (control; ○) or THL (120 mg; ■) on meal-stimulated plasma CCK release in 10 healthy volunteers. Inhibition of hydrolysis of dietary triglycerides by THL eliminated postprandial CCK release (P < 0.05). Data are mean ± SEM. Gastroenterology 1998 114, 123-129DOI: (10.1016/S0016-5085(98)70640-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 6 AUC of plasma CCK responses to intraduodenal sodium oleate perfusion with and without concomitant THL. Data are mean ± SEM. Gastroenterology 1998 114, 123-129DOI: (10.1016/S0016-5085(98)70640-7) Copyright © 1998 American Gastroenterological Association Terms and Conditions