A Systematic Review and Meta-analysis of D-dimer as a Rule-out Test for Suspected Acute Aortic Dissection Stephen E. Asha, MBBS, MMed (Clin Epi), James.

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Presentation transcript:

A Systematic Review and Meta-analysis of D-dimer as a Rule-out Test for Suspected Acute Aortic Dissection Stephen E. Asha, MBBS, MMed (Clin Epi), James W. Miers, BSc, MBBS Annals of Emergency Medicine Volume 66, Issue 4, Pages 368-378 (October 2015) DOI: 10.1016/j.annemergmed.2015.02.013 Copyright © 2015 American College of Emergency Physicians Terms and Conditions

Figure 1 Flowchart describing systematic literature search and study selection process. Annals of Emergency Medicine 2015 66, 368-378DOI: (10.1016/j.annemergmed.2015.02.013) Copyright © 2015 American College of Emergency Physicians Terms and Conditions

Figure 2 Individual study estimates and overall estimates of sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of D-dimer for the diagnosis of acute aortic dissection. A threshold of 0.50 μg/mL was used to define a positive D-dimer result. TP, True positive; FN, false negative; TN, true negative; FP, false positive; LR, likelihood ratio. *The discrepancy between the ratio and the reported positive likelihood ratio is because cells in 2×2 tables with zero value were handled by adding a 0.5 continuity correction. Annals of Emergency Medicine 2015 66, 368-378DOI: (10.1016/j.annemergmed.2015.02.013) Copyright © 2015 American College of Emergency Physicians Terms and Conditions

Figure 3 Acute aortic dissection risk score.3,24 Annals of Emergency Medicine 2015 66, 368-378DOI: (10.1016/j.annemergmed.2015.02.013) Copyright © 2015 American College of Emergency Physicians Terms and Conditions