Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia

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Presentation transcript:

Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia Miriam Pertegal, M.D., Ph.D., Francisco J. Fenoy, M.D., Ph.D., Moisés Hernández, M.D., Ph.D., Jaime Mendiola, Ph.D., M.P.H., Juan L. Delgado, M.D., Ph.D., Bárbara Bonacasa, Ph.D., Andrés Corno, Ph.D., Bernardo López, Ph.D., Vicente Bosch, M.D., Ph.D., Isabel Hernández, M.D., Ph.D. Fertility and Sterility Volume 105, Issue 1, Pages 134-143.e3 (January 2016) DOI: 10.1016/j.fertnstert.2015.09.019 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Placental catechol-O-methyltransferase (COMT) activity in vitro, measured as Vmax. (B) Plasma levels of 2-methoxyestradiol, according to fetal COMT rs4680 polymorphism. (C) Homocysteine plasma levels according to fetal MTHFR 677 C/T genotyping in control pregnancies and early- and late-onset preeclampsia. (D) Negative correlation in the total population sample of this study between maternal 2-methoxyestradiol (logarithmically transformed) and homocysteine levels (R = 0.522; R2 = 0.273; adjusted R2 = 0.01; P<.01). Data are presented as mean ± SE. *P<.05 compared with Val-Val in preeclamptic patients; †P<.05 compared with Val-Met within the same group; ‡P<.05 compared with CT; #P<.05 compared with term control; **P<.05 compared with late-onset preeclampsia. Fertility and Sterility 2016 105, 134-143.e3DOI: (10.1016/j.fertnstert.2015.09.019) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) Placental catechol-O-methyltransferase (COMT) expression according to fetal soluble (S) COMT rs4680 polymorphism. (B) Positive correlation in the total population sample between expression and COMT activity in vitro (Vmax) (R = 0.22; P<.01). (C) Western blot analysis of placental COMT expression according to fetal S-COMT rs4680 polymorphism; n = 4 for each genotype in control subjects and preeclampsia (PE) groups. The levels of actin protein were used as loading control. MB = membrane-bound. *P<.05 compared with Val-Met; #P<.05 compared with Val-Val. Fertility and Sterility 2016 105, 134-143.e3DOI: (10.1016/j.fertnstert.2015.09.019) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions