Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest Jennifer M. Hanna, MD, MBA, Jeffrey.

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Presentation transcript:

Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest Jennifer M. Hanna, MD, MBA, Jeffrey E. Keenan, MD, Hanghang Wang, MD, Nicholas D. Andersen, MD, Jeffrey G. Gaca, MD, Frederick W. Lombard, MB, ChB, Ian J. Welsby, MBBS, FRCA, G. Chad Hughes, MD The Journal of Thoracic and Cardiovascular Surgery Volume 151, Issue 2, Pages 376-382 (February 2016) DOI: 10.1016/j.jtcvs.2015.08.079 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Institutional transfusion algorithm schematic. In addition to standard treatment with the transfusion algorithm, the study cohort received 70 mg/kg human fibrinogen concentrate (HFC) upon separation from cardiopulmonary bypass (CPB) (blue shaded box). FFP, Fresh frozen plasma; TEG, thromboelastogram; ACT, activated clotting time; AMICAR, epsilon-aminocaproic acid; DDAVP, desmopressin; rFVIIa, recombinant activated Factor VII; PRBC, packed red blood cells; PLT, single-donor apheresis platelet unit; ICU, intensive care unit. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 376-382DOI: (10.1016/j.jtcvs.2015.08.079) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Consolidated Standards of Reporting Trials diagram. DHCA, Deep hypothermic circulatory arrest; CABG, coronary artery bypass grafting; HFC, human fibrinogen concentrate. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 376-382DOI: (10.1016/j.jtcvs.2015.08.079) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Use of fibrinogen concentrate as a hemostatic adjunct in aortic surgery. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 376-382DOI: (10.1016/j.jtcvs.2015.08.079) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions