ATM Creates a Veil of Transcriptional Silence

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ATM Creates a Veil of Transcriptional Silence Michael S.Y. Huen, Junjie Chen Cell Volume 141, Issue 6, Pages 924-926 (June 2010) DOI: 10.1016/j.cell.2010.05.035 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 DNA Double-Strand Break-Induced Silencing In cis (DISC) A model depicting how the kinase ATM (ataxia telangiectasia mutated) regulates gene silencing and the components involved in DNA double-strand break-induced silencing in cis (DISC). When a DNA double-strand break (DSB) is introduced at an actively transcribed region, it causes ATM activation and phosphorylation of histone variant H2AX. ATM promotes assembly of the H2A ubiquitin ligases RNF8 and RNF168 to the vicinity of the DSB, which triggers H2A ubiquitination (uH2A), leading to inhibition of transcription. Upon repair of the DSB or recovery from DNA-damage signaling, USP16 deubiquitinates uH2A, resulting in restored transcription. Red and yellow circles represent H2AX and H2A molecules, respectively. Cell 2010 141, 924-926DOI: (10.1016/j.cell.2010.05.035) Copyright © 2010 Elsevier Inc. Terms and Conditions