Effects of Sofosbuvir-Based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C Zobair M. Younossi,

Slides:

Advertisements

Similar presentations

Irritable Bowel Syndrome and Microscopic Colitis: A Systematic Review and Meta- analysis Eline J.C.A. Kamp, John S. Kane, Alexander C. Ford Clinical Gastroenterology.

Advertisements

MiraLAX Is Not as Effective as GoLytely in Bowel Cleansing Before Screening Colonoscopies Michael Hjelkrem, Joel Stengel, Mark Liu, David P. Jones, Stephen.

Patients With NASH and Cryptogenic Cirrhosis Are Less Likely Than Those With Hepatitis C to Receive Liver Transplants Jacqueline G. O'Leary, Carmen Landaverde,

The Role of Psychosocial Care in Adapting to Health Care Reform

Report of an International Workshop: Roadmap for Management of Patients Receiving Oral Therapy for Chronic Hepatitis B Emmet B. Keeffe, Stefan Zeuzem,

Saurabh Dawra, Vishal Sharma, Usha Dutta

Ezekiel Wong Toh Yoon, Kazuki Nishihara

Incorrect Calculation and Inappropriate Interpretation: Accuracy of International Guidelines for Identifying Significant Fibrosis in e Antigen–Negative.

Virologic, Clinical, and Immune Response Outcomes of Patients With Hepatitis C Virus– Associated Cryoglobulinemia Treated With Direct-Acting Antivirals

Nathalie Adda, Doug J. Bartels, Linda Gritz, Tara L

A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2008 Update Emmet B. Keeffe, Douglas T. Dieterich,

Coordinating Care in Patients With Cirrhosis

Shou–Jiang Tang, Feriyl Bhaijee

Katsunori Matsueda, Tatsuya Toyokawa

A Shocking Cystory Clinical Gastroenterology and Hepatology

Right Upper Quadrant Pain and a Normal Abdominal Ultrasound

Boceprevir With Peginterferon Alfa-2a–Ribavirin Is Effective for Previously Treated Chronic Hepatitis C Genotype 1 Infection Steven L. Flamm, Eric Lawitz,

Diffuse Gastric Wall Thickening: Appearances Can Be Deceptive

Report of an International Workshop: Roadmap for Management of Patients Receiving Oral Therapy for Chronic Hepatitis B Emmet B. Keeffe, Stefan Zeuzem,

Talya Salz, Robert S. Sandler Clinical Gastroenterology and Hepatology

Long-Term Outcomes of Nonalcoholic Fatty Liver Disease: From Nonalcoholic Steatohepatitis to Nonalcoholic Steatofibrosis Zobair M. Younossi Clinical.

Granular Cell Tumor in Colonic Polyp Found on Screening Colonoscopy

Virologic Response to Therapy Increases Health-Related Quality of Life for Patients With Chronic Hepatitis B Jeong Han Kim, So Young Kwon, Young Sok.

Pancreatic Duct Drainage for the Treatment of a Huge Pancreatic Cyst Associated With Autoimmune Pancreatitis Hiroyuki Matsubayashi, Toru Matsui, Hiroyuki.

Nghia H. Nguyen, Vincent Nguyen, Huy N. Trinh, Brian Lin, Mindie H

Interpreting Hepatitis B Surface Antigen Levels: Useful Clinical Test or Just Another Confusing Assay? Brian J. McMahon, MD, Brenna C. Simons, PhD Clinical.

Activity-Based Costing and Management in a Hospital-Based GI Unit

Prevalence and Challenges of Liver Diseases in Patients With Chronic Hepatitis C Virus Infection Ira M. Jacobson, Gary L. Davis, Hashem El–Serag, Francesco.

Rohan M. Modi, Christina A. Arnold, Peter P. Stanich

Patient-Reported Outcomes Following Treatment of Chronic Hepatitis C Virus Infection With Sofosbuvir and Velpatasvir, With or Without Voxilaprevir Zobair.

Thurarshen Jeyalingam, Yuto Shimamura, Christopher Teshima

Gastroenterology in a New Era of Accountability: Part 2

William D. Leslie Clinical Gastroenterology and Hepatology

New Models of Gastroenterology Practice

Issue Highlights Clinical Gastroenterology and Hepatology

Dushyant Singh, Reetu Singh, Wendell K. Clarkston

Effect of Human Immunodeficiency Virus and Antiretrovirals on Outcomes of Hepatitis C: A Systematic Review From an Epidemiologic Perspective Jennifer.

Histologic Changes in Liver Tissue From Patients With Chronic Hepatitis B and Minimal Increases in Levels of Alanine Aminotransferase: A Meta-analysis.

Levels of Alanine Aminotransferase Confound Use of Transient Elastography to Diagnose Fibrosis in Patients With Chronic Hepatitis C Virus Infection Elliot.

A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2008 Update Emmet B. Keeffe, Douglas T. Dieterich,

Brendan Campbell, Benny Liu, Taft Bhuket, Robert J. Wong

Peter Bytzer Clinical Gastroenterology and Hepatology

Cholelithiasis in a Patient With History of Cholecystectomy

Nonalcoholic Steatohepatitis Is the Fastest Growing Cause of Hepatocellular Carcinoma in Liver Transplant Candidates Zobair Younossi, Maria Stepanova,

Patient-Reported Outcomes of Cirrhosis

Rapid Resolution of Hepatitis C Virus–Associated Cryoglobulin Rash With Use of Direct- Acting Antivirals Eric Chak, Carl Schulze, Bruce A. Runyon Clinical.

Issue Highlights Clinical Gastroenterology and Hepatology

Effects of Different Coping Strategies on Physical and Mental Health of Patients With Irritable Bowel Syndrome Lilian Dindo, PhD Clinical Gastroenterology.

Alan Bonder, MD, Nezam H. Afdhal, MD

Nicolas Williet, William J. Sandborn, Laurent Peyrin–Biroulet

Rosanne M. Furse, Caroline J. Green, Anthony S. Mee

Hepatic Cyst? Clinical Gastroenterology and Hepatology

In-Hospital Mortality and Economic Burden Associated With Hepatic Encephalopathy in the United States From 2005 to 2009 Maria Stepanova, Alita Mishra,

Christos Konstantakis, Maria Karamesini, Christos Triantos

Hepatitis C Virus Infection, Age, and Hispanic Ethnicity Increase Mortality From Liver Cancer in the United States Zobair M. Younossi, Maria Stepanova

A 27-Year-Old Woman With Constipation: Diagnosis and Treatment

Minimal-Change Esophagitis on Narrow-Band Imaging

Clinical Gastroenterology and Hepatology

Issue Highlights Clinical Gastroenterology and Hepatology

Risk of Pancreatitis in Patients With Celiac Disease: Is Autoimmune Pancreatitis a Biologically Plausible Mechanism? John S. Leeds, David S. Sanders

Patients With NASH and Cryptogenic Cirrhosis Are Less Likely Than Those With Hepatitis C to Receive Liver Transplants Jacqueline G. O'Leary, Carmen Landaverde,

Rintaro Hashimoto, Akimichi Chonan

Adverse Outcomes: Why Bad Things Happen to Good People

M. Babitha Reddy, David M. Poppers, Cora Uram–Tuculescu

Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008 Zobair M. Younossi, Maria Stepanova,

Induction Pegylated Interferon Alfa-2b in Combination With Ribavirin in Patients With Genotypes 1 and 4 Chronic Hepatitis C: A Prospective, Randomized,

Rintaro Hashimoto, Akimichi Chonan

The Role of Psychosocial Care in Adapting to Health Care Reform

Fasiha Kanwal, Tuyen Hoang, Timothy Chrusciel, Jennifer R

Subcapsular Hepatic Fluid Collection Caused by Cardiac Dysfunction

Presentation transcript:

Effects of Sofosbuvir-Based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C Zobair M. Younossi, Maria Stepanova, Linda Henry, Edward Gane, Ira M. Jacobson, Eric Lawitz, David Nelson, Lynn Gerber, Fatema Nader, Sharon Hunt Clinical Gastroenterology and Hepatology Volume 12, Issue 8, Pages 1349-1359.e13 (August 2014) DOI: 10.1016/j.cgh.2013.11.032 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 PROs in FUSION: FACIT-F (A), CLDQ-HCV (B), and WPAI (C). FACIT-F scores are normalized to 0-1 range. Red circles and triangles represent the significance of the changes from the baseline for the respective scales. Clinical Gastroenterology and Hepatology 2014 12, 1349-1359.e13DOI: (10.1016/j.cgh.2013.11.032) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 PROs in NEUTRINO: FACIT-F (A), CLDQ-HCV (B), and WPAI (C). FACIT-F scores are normalized to 0-1 range. Red circles and triangles represent the significance of the changes from the baseline for the respective scales. Clinical Gastroenterology and Hepatology 2014 12, 1349-1359.e13DOI: (10.1016/j.cgh.2013.11.032) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Changes in PROs 12 weeks after treatment. *Significant improvement (P < .05) from baseline. Clinical Gastroenterology and Hepatology 2014 12, 1349-1359.e13DOI: (10.1016/j.cgh.2013.11.032) Copyright © 2014 AGA Institute Terms and Conditions