Angela R. Baerwald, Ph. D. , Olufemi A. Olatunbosun, M. D. , Roger A

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Presentation transcript:

Effects of oral contraceptives administered at defined stages of ovarian follicular development Angela R. Baerwald, Ph.D., Olufemi A. Olatunbosun, M.D., Roger A. Pierson, M.S., Ph.D. Fertility and Sterility Volume 86, Issue 1, Pages 27-35 (July 2006) DOI: 10.1016/j.fertnstert.2005.12.046 Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Follicle diameter profiles (■) and serum concentrations of E2-17β (○) and LH (◊) for women randomized to initiate OC use at 10 mm. Follicles that grew to 10–14 mm and then regressed (A) and grew to >14 mm and then regressed (B) are shown separately. Data are centralized to the day of randomization at 10 mm. Baerwald. Follicle growth and oral contraception. Fertil Steril 2006. Fertility and Sterility 2006 86, 27-35DOI: (10.1016/j.fertnstert.2005.12.046) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Follicle diameter profiles (■) and serum concentrations of E2-17β (○) and LH (◊) for women randomized to initiate OC at 14 mm. Follicles that grew to 14 ± 1 mm and then regressed (A), grew to >14 mm and then regressed (B), ovulated (C), or developed into anovulatory follicular cysts (D) are shown separately. Data are centralized to the day of randomization at 14 mm. Baerwald. Follicle growth and oral contraception. Fertil Steril 2006. Fertility and Sterility 2006 86, 27-35DOI: (10.1016/j.fertnstert.2005.12.046) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Follicle diameter profiles (■, ●) and serum concentrations of E2-17β (○) and LH (◊) for women randomized to initiate OC at 18 mm. Follicles that ovulated (A), formed hemorrhagic anovulatory follicles (HAF) (B), ovulated (follicle 1) and ovulated (follicle 2; C), ovulated (follicle 1) and formed HAF (follicle 2; D), and ovulated (follicle 1) and regressed (follicle 2; E) are shown separately. Data are centralized to the day of randomization at 18 mm. Baerwald. Follicle growth and oral contraception. Fertil Steril 2006. Fertility and Sterility 2006 86, 27-35DOI: (10.1016/j.fertnstert.2005.12.046) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Profiles of endometrial thickness (A) and pattern (B) in women randomized to initiate OC at follicle diameters of 10 (●), 14 (◊), and 18 (■) mm. Data are centralized to the day of respective randomization. Baerwald. Follicle growth and oral contraception. Fertil Steril 2006. Fertility and Sterility 2006 86, 27-35DOI: (10.1016/j.fertnstert.2005.12.046) Copyright © 2006 American Society for Reproductive Medicine Terms and Conditions