Novel Bioengineered Small Caliber Vascular Graft With Excellent One-Month Patency Yosuke Ishii, MD, Russell T. Kronengold, PhD, Renu Virmani, MD, Elias.

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Presentation transcript:

Novel Bioengineered Small Caliber Vascular Graft With Excellent One-Month Patency Yosuke Ishii, MD, Russell T. Kronengold, PhD, Renu Virmani, MD, Elias A. Rivera, MHS, Scott M. Goldman, MS, Ericka J. Prechtel, MS, Richard B. Schuessler, PhD, Ralph J. Damiano, MD The Annals of Thoracic Surgery Volume 83, Issue 2, Pages 517-525 (February 2007) DOI: 10.1016/j.athoracsur.2006.09.053 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 The synthetic small caliber graft with a bioengineered microporous matrix that did not contain cells and required no preclotting. The Annals of Thoracic Surgery 2007 83, 517-525DOI: (10.1016/j.athoracsur.2006.09.053) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 The percentage of heparin eluted from the graft (in vitro). The Annals of Thoracic Surgery 2007 83, 517-525DOI: (10.1016/j.athoracsur.2006.09.053) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Explanted heparin-sirolimus (HS) (top) and heparin-sirolimus vascular endothelial growth factor (HSV) (bottom) grafts. There was no stenosis at the anastomotic sites and center of the grafts. The Annals of Thoracic Surgery 2007 83, 517-525DOI: (10.1016/j.athoracsur.2006.09.053) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 (A) Graft compliance at preoperative (white) and postoperative phase (black). (B) Graft tensile strength at preoperative (white) and postoperative phase (black). (H = heparin alone; HS = heparin-sirolimus; HSV = heparin-sirolimus vascular endothelial growth factor.) The Annals of Thoracic Surgery 2007 83, 517-525DOI: (10.1016/j.athoracsur.2006.09.053) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Serial change of endothelialization (top) and cellular infiltration (bottom) at anastomotic sites and center of the grafts. (A) Percentage of grafts that had endothelialization or cellular infiltration. (B) Histologic index, which was calculated by dividing the sum of the grade by the number of sample grafts (grade/n). (Open bars = anastomosis site; hatched bars = center of graft.) The Annals of Thoracic Surgery 2007 83, 517-525DOI: (10.1016/j.athoracsur.2006.09.053) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Histology and immunohistochemical data of the heparin-sirolimus (HS) grafts at 4 weeks. Moderate cellular infiltration was observed in the graft wall in hematoxylin-eosin (H-E) stain. Normal-appearing endothelial cells were aligned with the blood flow (right: arrows). There was moderate neocapillary formation in the graft wall (left: arrows). Clumps of red blood cells were observed inside the neocapillaries. The Annals of Thoracic Surgery 2007 83, 517-525DOI: (10.1016/j.athoracsur.2006.09.053) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 7 Histology and immunohistochemical data of the heparin-sirolimus vascular endothelial growth factor grafts at 4 weeks. Moderate cellular infiltration was observed in the graft wall in hematoxylin-eosin (H-E) stain. The Annals of Thoracic Surgery 2007 83, 517-525DOI: (10.1016/j.athoracsur.2006.09.053) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions