Association of skewed X chromosome inactivation and idiopathic recurrent spontaneous abortion: a systematic review and meta-analysis  Yilun Sui, Qianqian.

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Presentation transcript:

Association of skewed X chromosome inactivation and idiopathic recurrent spontaneous abortion: a systematic review and meta-analysis  Yilun Sui, Qianqian Chen, Xiaoxi Sun  Reproductive BioMedicine Online  Volume 31, Issue 2, Pages 140-148 (August 2015) DOI: 10.1016/j.rbmo.2015.05.007 Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 PRISMA flow chart for study selection. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 The association between skewed X chromosome inactivation and idiopathic recurrent spontaneous abortion. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Funnel plot to assess publication and related biases. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Association between highly skewed X chromosome inactivation (>85% or ≥85%) and idiopathic recurrent spontaneous abortion. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 5 Association of extremely skewed X chromosome inactivation (>90% or ≥90%) and idiopathic recurrent spontaneous abortion. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 6 Association of extremely skewed X chromosome inactivation (≥95%) and idiopathic recurrent spontaneous abortion. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 7 Association of extremely skewed X chromosome inactivation (>90% or ≥90%) and idiopathic recurrent spontaneous abortion when defined as three or more losses. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 8 Association of extremely skewed X chromosome inactivation (>90% or ≥90%) and idiopathic recurrent spontaneous abortion when defined as two or more losses. Reproductive BioMedicine Online 2015 31, 140-148DOI: (10.1016/j.rbmo.2015.05.007) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions