PPARγ: Welcoming the New Kid on the CML Stem Cell Block

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PPARγ: Welcoming the New Kid on the CML Stem Cell Block Beth Apsel Winger, Neil P. Shah Cancer Cell Volume 28, Issue 4, Pages 409-411 (October 2015) DOI: 10.1016/j.ccell.2015.09.017 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Piolitazone Synergizes with Imatinib, But TKIs Alone Deplete BCR-ABL Transcripts over Time (A) Imatinib is effective against dividing CML cells, but not CML stem cells. (B) Pioglitazone makes CML stem cells accessible to imatinib by decreasing STAT5 transcription, thus decreasing signals that maintain stem cell quiescence. Double red lines, resistance; orange lines, transcriptional regulation; weight of line indicates strength of signal (dashed line, weakest; bold line, strongest). (C) BCR-ABL transcripts decrease with time in patients on continuous imatinib therapy, making the benefit of adding pioglitazone to imatinib unclear. Cancer Cell 2015 28, 409-411DOI: (10.1016/j.ccell.2015.09.017) Copyright © 2015 Elsevier Inc. Terms and Conditions