L. I. Cortínez, B. J. Anderson, A Penna, L Olivares, H. R. Muñoz, N. H

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Presentation transcript:

Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model L.I. Cortínez, B.J. Anderson, A Penna, L Olivares, H.R. Muñoz, N.H.G. Holford, M.M.R.F. Struys, P Sepulveda British Journal of Anaesthesia Volume 105, Issue 4, Pages 448-456 (October 2010) DOI: 10.1093/bja/aeq195 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 PC-VPC for the index study. The dashed blue lines present the 5th and 95th percentiles and the solid orange line depicts the model predicted median. The shaded grey area is the 90% confidence interval for the prediction percentiles. The 90% prediction interval and median for prediction corrected observed data are shown as lines with closed circles. (a) The first 20 min and (b) from 20 to 200 min. British Journal of Anaesthesia 2010 105, 448-456DOI: (10.1093/bja/aeq195) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 PC-VPC for the pooled analysis. See Fig. 1 for legend. British Journal of Anaesthesia 2010 105, 448-456DOI: (10.1093/bja/aeq195) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 Population prediction corrected visual predictive checks. See Fig. 1 for legend. The 90% prediction interval from the pooled analysis encompasses time–concentration profiles from the index study. Dosing comprised propofol 2 mg kg−1 at 200 mg min−1. An infusion of 10 mg kg−1 h−1 was started at 5 min and ran for 5 min. This was then decreased to 8 mg kg−1 h−1 for 20 min. The infusion was further decreased to 6 mg kg−1 h−1 for the next 30 min before slowing to 4.8 mg kg−1 h−1 for 120 min. British Journal of Anaesthesia 2010 105, 448-456DOI: (10.1093/bja/aeq195) Copyright © 2010 The Author(s) Terms and Conditions

Fig 4 Simulated propofol infusion rates of different PK models to reach and maintain a plasma concentration of 3.0 µg ml−1. The simulated case is a 30 yr woman with a TBW of 140 kg and a height of 160 cm (BMI 54.7 kg m−2). British Journal of Anaesthesia 2010 105, 448-456DOI: (10.1093/bja/aeq195) Copyright © 2010 The Author(s) Terms and Conditions

Fig 5 Simulated propofol time–concentration profiles predicted by three different PK models after a 3 h infusion with a plasma target of 3.0 µg ml−1 The simulated case is a 30 yr woman with a TBW of 140 kg and a height of 160 cm (BMI 54.7 kg m−2). Marsh (TBW) and Marsh (weight-adjusted) are indistinguishable since rate constants in Marsh PK parameters are not influenced by weight. British Journal of Anaesthesia 2010 105, 448-456DOI: (10.1093/bja/aeq195) Copyright © 2010 The Author(s) Terms and Conditions