Efficacy and safety of Creon�� 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis Bruce C. Trapnell, Karen Maguiness, Gavin.

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Presentation transcript:

Efficacy and safety of Creon�� 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis Bruce C. Trapnell, Karen Maguiness, Gavin R. Graff, David Boyd, Katrin Beckmann, Steven Caras Journal of Cystic Fibrosis Volume 8, Issue 6, Pages 370-377 (December 2009) DOI: 10.1016/j.jcf.2009.08.008 Copyright © 2009 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Study design and patient disposition. AE: adverse event. Journal of Cystic Fibrosis 2009 8, 370-377DOI: (10.1016/j.jcf.2009.08.008) Copyright © 2009 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Individual subject data for (A) coefficient of fat absorption (CFA) and (B) coefficient of nitrogen absorption (CNA) during treatment with Creon or placebo. Journal of Cystic Fibrosis 2009 8, 370-377DOI: (10.1016/j.jcf.2009.08.008) Copyright © 2009 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Effect of Creon on abdominal pain (A, B), stool consistency (C, D), and flatulence (E, F), and Clinical Global Impression of Disease Severity (CGI) assessed by investigators (G) and by subjects (H). Journal of Cystic Fibrosis 2009 8, 370-377DOI: (10.1016/j.jcf.2009.08.008) Copyright © 2009 European Cystic Fibrosis Society. Terms and Conditions