Therapeutic decisions by number needed to treat and survival gains: a cross-sectional survey of lipid-lowering drug recommendations by Peder A Halvorsen,

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Presentation transcript:

Therapeutic decisions by number needed to treat and survival gains: a cross-sectional survey of lipid-lowering drug recommendations by Peder A Halvorsen, Torbjørn F Wisløff, Henrik Støvring, Olaf Aasland, and Ivar Sønbø Kristiansen BJGP Volume 61(589):e477-e483 August 1, 2011 ©2011 by British Journal of General Practice

Hypothetical survival curves illustrating estimation of different effect measures. Hypothetical survival curves illustrating estimation of different effect measures. Vertical lines: differences between proportions at fixed points in time; that is, absolute risk reduction (ARR). Number needed to treat is the inverse value of ARR; that is, 1/ARR. Area between curves: gain in (event-free) life expectancy. Peder A Halvorsen et al. Br J Gen Pract 2011;61:e477-e483 ©2011 by British Journal of General Practice

Study flow diagram. Study flow diagram. GPs and internists were randomly assigned to clinical vignettes presenting the benefit of a hypothetical lipid-lowering drug therapy, ‘neostatin’, in terms of number needed to treat (NNT) to prevent one incident of cardiovascular disease after 24 years of therapy, or gain in disease-free survival on lifelong therapy. Peder A Halvorsen et al. Br J Gen Pract 2011;61:e477-e483 ©2011 by British Journal of General Practice