Fig. 5. Accelerated NASH-driven fibrogenesis in obese IFN-γ−/− mice is characterized by severe eosinophilic inflammation during TGF-β blockade. Accelerated.

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Fig. 5. Accelerated NASH-driven fibrogenesis in obese IFN-γ−/− mice is characterized by severe eosinophilic inflammation during TGF-β blockade. Accelerated NASH-driven fibrogenesis in obese IFN-γ−/− mice is characterized by severe eosinophilic inflammation during TGF-β blockade. (A) WT (circles) and IFN-γ−/− (squares) mice were maintained for 20 weeks on normal diet (filled symbols) or HFD (open symbols) and received 4 weeks of biweekly control Ig or anti–TGF-β (250 μg each). Liver weight and liver index were determined (n = 9 to 14), and fibrotic fraction was calculated from picrosirius red–stained liver sections (n = 3 to 12). (B) Expression of interstitial collagen genes. Periostin, IL-13, and CCL11 expression were quantified from whole liver tissue (n = 6 to 14). (C) Hepatic eosinophils were measured by flow cytometry analysis of Siglec-F+ cells among CD45 leukocytes (n = 7 to 9) (D). Eosinophils were observed in hepatic tissue by Giemsa-stained liver sections (scale bars, 50 μm) (E) and by immunofluorescence staining of tissue sections for Siglec-F+ cells (scale bars, 125 μm) (F). WT mice were maintained for 40 weeks on normal diet (filled symbols) or HFD (open symbols) and received 4 weeks of biweekly control Ig (circles), anti–TGF-β (squares), or combined anti–TGF-β and IL-13 mAbs (triangles) (250 μg each). (G) Expression of col3a1 and col6a1 from whole liver tissue were assessed by qPCR (n = 3 to 6). All data points represent a single mouse, and representative or pooled data from two or more independent experiments are shown (two-tailed t tests, n = 2 to 10; *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.0001). Kevin M. Hart et al., Sci Transl Med 2017;9:eaal3694 Published by AAAS